Fluorescent probes for sensing and imaging biological hydrogen sulfide.

Fluorescent probes for sensing and imaging biological hydrogen sulfide.
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DOI:
10.1016/j.cbpa.2012.07.014
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发表时间:
2012-12
影响因子:
7.8
通讯作者:
Chang, Christopher J.
Chang, Christopher J.
中科院分区:
生物学2区
文献类型:
--
作者:
Lin, Vivian S.;Chang, Christopher J.

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硫化氢(H_2S)长期以来被认为是生物系统中的一种有毒分子。然而,新出现的研究现在将这种活性硫物种的受控通量与细胞调节和信号事件联系起来,类似于其他小分子信使,如一氧化氮、过氧化氢和一氧化碳。对硫化氢具有高选择性的荧光小分子指示剂的发展为研究硫化氢的产生、运输及其下游的生理和/或病理效应提供了一条很有前途的途径。
Hydrogen sulfide (H2S) has long been recognized as a toxic molecule in biological systems. However, emerging studies now link controlled fluxes of this reactive sulfur species to cellular regulation and signaling events akin to other small molecule messengers, such as nitric oxide, hydrogen peroxide, and carbon monoxide. Progress in the development of fluorescent small-molecule indicators with high selectivity for hydrogen sulfide offers a promising approach for studying its production, trafficking, and downstream physiological and/or pathological effects.
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