Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans.
Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans.
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DOI：
10.4143/crt.2020.478
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发表时间：
2021-07
影响因子：
4.6
通讯作者：
Kweon SS
中科院分区：
文献类型：
--
作者：
Choi CK;Shin MH;Cho SH;Kim HY;Zheng W;Long J;Kweon SS
Excessive alcohol consumption has been linked to an increased risk of colorectal cancer (CRC). We evaluated the association between alcohol-related genetic variants and CRC risk. The study cohort consisted of 5,435 CRC cases and 3,553 population-based cancer-free controls. Genotype data were generated from germline DNA using the Infinium OncoArray-500K BeadChip in 2,535 cases and 2,287 controls and the Infinium Multi-Ethnic Global BeadChip in 2,900 cases and 1,266 controls. The associations between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol dehydrogenase 1B (ADH1B) rs1229984 polymorphisms and CRC risk were assessed using multivariate logistic regression analyses. Compared with the major homozygous ALDH2 genotype (GG), heterozygous or minor homozygous ALDH2 genotype (GA or AA, related to a low alcohol consumption) was significantly associated with a reduced risk for CRC in men (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.68 to 0.90), but not in women (OR, 0.70; 95% CI, 0.47 to 1.05). A stronger association was found among regular drinkers (OR, 0.58; 95% CI, 0.47 to 0.71 in men and OR, 0.33; 95% CI, 0.18 to 0.58 in women). No association of CRC risk with ADH1B rs1229984 genotype was found. The association between alcohol-related combined genotypes and risk of CRC was significant (p for linear=0.001). The combined genotype with the highest genetically predicted alcohol consumption (ALDH2 rs671 GG and ADH1B rs1229984 AG/GG) was associated with a high risk for CRC (OR, 1.35; 95% CI, 1.11 to 1.63). Our study provides strong evidence for a possible causal association between alcohol consumption and CRC risk.
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影响因子：
3.7
作者：
Zhao H;Liu KJ;Lei ZD;Lei SL;Tian YQ
通讯作者：
Tian YQ
影响因子：
5.4
作者：
Roerecke M;Tobe SW;Kaczorowski J;Bacon SL;Vafaei A;Hasan OSM;Krishnan RJ;Raifu AO;Rehm J
通讯作者：
Rehm J
影响因子：
5.7
作者：
Yin, Guang;Kono, Suminori;Imaizumi, Nobutoshi
通讯作者：
Imaizumi, Nobutoshi
影响因子：
168.9
作者：
Millwood, Iona Y.;Walters, Robin G.;Chen, Zhengming
通讯作者：
Chen, Zhengming
影响因子：
6.4
作者：
McNabb, Sarah;Harrison, Tabitha A.;Peters, Ulrike
通讯作者：
Peters, Ulrike