Geometric constraints during epithelial jamming.
Geometric constraints during epithelial jamming.
复制标题
DOI：
10.1038/s41567-018-0089-9
复制
发表时间：
2018-06
期刊：
影响因子：
19.6
通讯作者：
Fredberg JJ
中科院分区：
文献类型：
--
作者：
Atia L;Bi D;Sharma Y;Mitchel JA;Gweon B;Koehler S;DeCamp SJ;Lan B;Kim JH;Hirsch R;Pegoraro AF;Lee KH;Starr JR;Weitz DA;Martin AC;Park JA;Butler JP;Fredberg JJ
当损伤愈合、胚胎发育或癌细胞扩散时，上皮细胞会系统性地改变其形状。在这些过程中，细胞形状被广泛研究，而细胞间形状的变化通常被认为是生物噪声。但是细胞的形状和变异从何而来呢？在这里，我们报告，细胞形状和形状可变性是相互约束的关系，是纯粹的几何。这种关系被证明控制着各种各样的过程，如从非哮喘或哮喘供体培养的假分层支气管上皮层的成熟，以及果蝇胚胎中腹沟的形成。在这些和其他上皮系统中，形状变异性瓦解为一个共同的分布家族。这种分布反过来又由细胞-细胞相互作用的机械理论来解释，该理论表明，随着层逐渐变得更加拥挤，细胞形状变得越来越不长，变化也越来越少。这些发现表明，阻塞和几何之间的联系跨越了生物体和惰性阻塞系统，因此超越了系统细节。尽管任何完整的细胞形状和细胞堆积理论都需要分子事件，但观察结果表明，在更大的组织尺度上，干扰行为设置了压倒一切的几何约束。
As an injury heals, an embryo develops, or a carcinoma spreads, epithelial cells systematically change their shape. In each of these processes cell shape is studied extensively whereas variability of shape from cell-to-cell is regarded most often as biological noise. But where do cell shape and its variability come from? Here we report that cell shape and shape variability are mutually constrained through a relationship that is purely geometrical. That relationship is shown to govern processes as diverse as maturation of the pseudostratified bronchial epithelial layer cultured from non-asthmatic or asthmatic donors, and formation of the ventral furrow in the Drosophila embryo. Across these and other epithelial systems, shape variability collapses to a family of distributions that is common to all. That distribution, in turn, is accounted for by a mechanistic theory of cell-cell interaction showing that cell shape becomes progressively less elongated and less variable as the layer becomes progressively more jammed. These findings suggest a connection between jamming and geometry that spans living organisms and inert jammed systems, and thus transcends system details. Although molecular events are needed for any complete theory of cell shape and cell packing, observations point to the hypothesis that jamming behavior at larger scales of organization sets overriding geometrical constraints.
登录
查看更多内容
影响因子：
64.8
作者：
Martin, Adam C.;Kaschube, Matthias;Wieschaus, Eric F.
通讯作者：
Wieschaus, Eric F.
影响因子：
2.3
作者：
Hales, Thomas;Adams, Mark;Zumkeller, Roland
通讯作者：
Zumkeller, Roland
影响因子：
2.4
作者：
Henkes, Silke;Fily, Yaouen;Marchetti, M. Cristina
通讯作者：
Marchetti, M. Cristina
影响因子：
2.4
作者：
Aste, T.;Di Matteo, T.
通讯作者：
Di Matteo, T.
影响因子：
9.2
作者：
Farhadifar, Reza;Roeper, Jens-Christian;Juelicher, Frank
通讯作者：
Juelicher, Frank