The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis.
The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis.
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DOI：
10.1289/ehp.7633
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发表时间：
2005-06
影响因子：
10.4
通讯作者：
Leranth C
中科院分区：
文献类型：
--
作者：
MacLusky NJ;Hajszan T;Leranth C
双酚A（BPA）是一种雌激素化学品，广泛用于塑料和环氧树脂的生产。由于双酚A会从塑料食品和饮料容器以及用于假牙和密封剂的含双酚A塑料中滤出，因此人类接触这种化合物的可能性很大。在这篇文章中，我们表明，治疗卵巢切除大鼠BPA剂量依赖性抑制雌激素诱导的海马CA 1区锥体神经元树突棘突触的形成。BPA的显著抑制作用仅在40 μg/kg的剂量下观察到，低于目前美国环境保护局对人类暴露的每日参考限值。由于突触重塑已被假定为有助于雌激素对海马依赖性记忆的快速影响，这些数据表明，环境BPA暴露可能会干扰认知功能的正常性别差异的发展和表达，通过抑制雌激素依赖性海马突触的形成。它也可能加剧正常衰老过程中观察到的海马功能受损，因为内源性雌激素产生下降。
Bisphenol A (BPA) is an estrogenic chemical that is widely used in the manufacture of plastics and epoxy resins. Because BPA leaches out of plastic food and drink containers, as well as the BPA-containing plastics used in dental prostheses and sealants, considerable potential exists for human exposure to this compound. In this article we show that treatment of ovariectomized rats with BPA dose-dependently inhibits the estrogen-induced formation of dendritic spine synapses on pyramidal neurons in the CA1 area of the hippocampus. Significant inhibitory effects of BPA were observed at a dose of only 40 μg/kg, below the current U.S. Environmental Protection Agency reference daily limit for human exposure. Because synaptic remodeling has been postulated to contribute to the rapid effects of estrogen on hippocampus-dependent memory, these data suggest that environmental BPA exposure may interfere with the development and expression of normal sex differences in cognitive function, via inhibition of estrogen-dependent hippocampal synapse formation. It may also exacerbate the impairment of hippocampal function observed during normal aging, as endogenous estrogen production declines.
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影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
DOI：
10.1080/02652030210134236
发表时间：
2003-07-01
期刊：
FOOD ADDITIVES AND CONTAMINANTS
影响因子：
--
作者：
Brede, C;Fjeldal, P;Herikstad, H
通讯作者：
Herikstad, H
影响因子：
4.4
作者：
Gandy, S
通讯作者：
Gandy, S
影响因子：
4.8
作者：
MacLusky, NJ;Luine, VN;Leranth, C
通讯作者：
Leranth, C
影响因子：
5.3
作者：
Leranth, C;Hajszan, T;MacLusky, NJ
通讯作者：
MacLusky, NJ