Myeloid cell thrombus and fetal vascular malperfusion in placentas with transient abnormal myelopoiesis
Myeloid cell thrombus and fetal vascular malperfusion in placentas with transient abnormal myelopoiesis
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短暂性骨髓细胞生成异常的胎盘中骨髓细胞血栓和胎儿血管灌注不良
DOI：
10.1007/s00428-022-03289-5
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sato Y
中科院分区：
文献类型：
--
作者：
Tomimori K;Kodama Y;Tanaka H;Yamashita A;Gi T;Asada Y;Do K;Katsuragi S;Sato Y
短暂性异常骨髓生成（TAM），也称为短暂性骨髓增生性疾病或短暂性白血病，是一种自我消退的肿瘤，折磨患有21三体的婴儿。最近的一篇综述文章记录了TAM胎盘中的“髓样细胞血栓（MCT）”和“胎儿血管灌注不良（FVM）”，尽管特征性TAM胎盘结果尚未阐明。在这里，我们比较了临床和病理学胎盘21三体综合征患者与TAM或没有。在13例21三体综合征患者中，我们发现6个胎盘有TAM，7个胎盘没有TAM。6例TAM胎盘包括2例死胎。显微镜下，所有病例均观察到MCT，TAM病例中FVM的发生率较高（50%）。免疫组织化学显示MCT为富含血小板的血栓。根据TAM的存在或不存在对胎盘进行分组，随后进行比较。临床上，TAM组胎心率异常及胎儿或新生儿死亡率明显增高。病理学上，TAM组胎盘重量较无TAM组明显增加，MCT发生率明显高于无TAM组。此外，FVM的发生率较高的胎盘与TAM，但这种差异没有统计学意义。我们认为MCT是TAM胎盘的诊断特征，可能与不良的胎儿结局相关。
Transient abnormal myelopoiesis (TAM), also known as transient myeloproliferative disorder or transient leukemia, is a self-regressing neoplasia that afflicts infants with trisomy 21. A recent review article documented “myeloid cell thrombus (MCT)” and “fetal vascular malperfusion (FVM)” in placentas with TAM, although the characteristic TAM placental findings have not been clarified. Here, we compared the clinical and pathological placental findings between trisomy 21 patients with or without TAM. In 13 cases of trisomy 21, we identified six placentas with TAM and seven placentas without TAM. The six placentas with TAM included two stillborn cases. Microscopically, MCT was noted in all the cases, and a high incidence of FVM (50%) was observed in TAM cases. Immunohistochemically, MCT was found to be a platelet-rich thrombus. The placentas were grouped according to the presence or absence of TAM and subsequently compared. Clinically, the incidences of abnormal fetal heart rate pattern and fetal or neonatal death were significantly higher in TAM cases. Pathologically, placenta in TAM cases weighted more than those in cases without TAM, and the incidence of MCT was significantly higher in placentas with TAM. Moreover, the incidence of FVM was higher in placentas with TAM, but this difference was not statistically significant. We propose that MCT is a diagnostic feature of placentas with TAM and may be associated with poor fetal outcomes.
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DOI：
10.1080/15513819609168713
发表时间：
1996-11-01
期刊：
PEDIATRIC PATHOLOGY & LABORATORY MEDICINE
影响因子：
--
作者：
Pinar, H;Sung, CJ;Singer, DB
通讯作者：
Singer, DB
孕产妇和新生儿骨髓增生性疾病的胎盘病理学
影响因子：
7.2
作者：
S. Lentz;Carol C. Coulson;C. Gocke;Amy P. Fantaskey
通讯作者：
Amy P. Fantaskey
唐氏综合症同卵双胞胎中不同的 GATA1 点突变和三胞胎妊娠导致的短暂性骨髓生成异常：病例报告和文献综述。
影响因子：
3.5
作者：
Liqun Yin;M. Lovell;Michael L Wilson;Q. Wei;Xiayuan Liang
通讯作者：
Xiayuan Liang
唐氏综合症相关短暂性异常骨髓生成的胎盘病理学。
影响因子：
4.6
作者：
Enoch Kuo;Asangi R. Kumarapeli
通讯作者：
Asangi R. Kumarapeli
涉及胎盘母腔的 21 三体性相关短暂性骨髓细胞生成异常：一例报告及文献综述
影响因子：
1.9
作者：
Q. Dai;Vishnu V. B. Reddy;J. Choi;O. Faye
通讯作者：
O. Faye