RNA is taking its Toll: Impact of RNA‐specific Toll‐like receptors on health and disease
RNA is taking its Toll: Impact of RNA‐specific Toll‐like receptors on health and disease
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RNA 正在发挥作用：RNA 特异性 Toll 样受体对健康和疾病的影响
作者：
Vierbuchen T;Stein K;Heine H
RNA敏感的Toll样受体(TLRs)通常被描述为先天免疫系统的抗病毒受体。然而，过去十年的情况表明，这些受体的功能和相关性要复杂得多。它们被发现对于检测各种细菌、古细菌和真核微生物是必不可少的，并有助于区分死亡和活着的微生物。被触发的细胞因子和干扰素反应谱有可能提高下一代疫苗的效力，并可能防止哮喘和过敏的发展。然而，识别外来RNA的能力是有代价的，因为受损的宿主细胞也会释放核酸，可能会引发不适当的免疫反应。因此，RNA感应TLRs在各种自身免疫性疾病中发挥关键作用也就不足为奇了。然而，有希望的新的抑制剂和拮抗剂即将出现，以改进他们的治疗。
RNA‐sensing Toll‐like receptors (TLRs) are often described as antiviral receptors of the innate immune system. However, the past decade has shown that the function and relevance of these receptors are far more complex. They were found to be essential for the detection of various bacterial, archaeal, and eukaryotic microorganisms and facilitate the discrimination between dead and living microbes. The cytokine and interferon response profile that is triggered has the potential to improve the efficacy of next‐generation vaccines and may prevent the development of asthma and allergy. Nevertheless, the ability to recognize foreign RNA comes with a cost as also damaged host cells can release nucleic acids that might induce an inappropriate immune response. Thus, it is not surprising that RNA‐sensing TLRs play a key role in various autoimmune diseases. However, promising new inhibitors and antagonists are on the horizon to improve their treatment.
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RIG-I 样受体的免疫信号传导。
影响因子：
32.4
作者：
Loo YM;Gale M Jr
通讯作者：
Gale M Jr
古菌脂质粘膜疫苗佐剂和递送系统
影响因子：
6.2
作者：
G. B. Patel;Wangxue Chen
通讯作者：
Wangxue Chen
DOI：
10.3390/life5021333
发表时间：
2015-05-05
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Horz HP
通讯作者：
Horz HP
树突状细胞对乳酸乳球菌 G121 及其 RNA 的内体识别是其过敏保护作用的关键
DOI：
10.1016/j.jaci.2016.06.018
发表时间：
2016
期刊：
The Journal of Allergy and Clinical Immunology
影响因子：
--
作者：
K. Stein;S. Brand;André Jenckel;A. Sigmund;Zhijian J. Chen;C. Kirschning;M. Kauth;H. Heine
通讯作者：
H. Heine
影响因子：
32.4
作者：
Nakayamada S;Kanno Y;Takahashi H;Jankovic D;Lu KT;Johnson TA;Sun HW;Vahedi G;Hakim O;Handon R;Schwartzberg PL;Hager GL;O'Shea JJ
通讯作者：
O'Shea JJ