Chicken-origin Cluster 3.2 Tembusu virus exhibits higher infectivity than duck-origin Cluster 2 Tembusu virus in chicks.
Chicken-origin Cluster 3.2 Tembusu virus exhibits higher infectivity than duck-origin Cluster 2 Tembusu virus in chicks.
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鸡源 Cluster 3.2 Tembusu 病毒在雏鸡中表现出比鸭源 Cluster 2 Tembusu 病毒更高的感染性
DOI：
10.3389/fvets.2023.1152802
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发表时间：
2023
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
2020年，鸡源第三群天布苏病毒（TMUV）在中国蛋鸡中引发了以降蛋综合征为特征的疾病暴发。本研究从华南地区产蛋综合征的蛋鸡组织样本中分离出一株TMUV- gx。系统发育分析将TMUV- gx归为TMUV集群3.2，与鸭群中流行的TMUV集群2不同。为研究TMUV-GX在鸡鸭体内的传染性和致病性，采用SPF雏鸡和SPF雏鸭分别接种相同剂量的TMUV-GX。作为比较，在雏鸡和雏鸭中建立鸭源2型簇毒株TMUV-JM感染组。与鸡源TMUV-JM较低的传染性和致病性相比，鸡源TMUV-GX在多组织中表现出较高的复制能力，并引起组织病理损伤。此外，TMUV-GX在雏鸭中的复制能力与TMUV-JM相当。本研究发现鸡源3.2型TMUV在雏鸭中具有较高的传染性，提示鸡源3.2型TMUV具有广泛感染鸡鸭的生物学基础。
In 2020, a chicken-origin Cluster 3 Tembusu virus (TMUV) caused outbreaks of a disease characterized by egg-drop syndrome in laying hens in China. In the present study, a TMUV strain, TMUV-GX, was isolated from tissue samples of laying hens with egg drop syndrome in south China. Phylogenetic analysis grouped TMUV-GX into TMUV Cluster 3.2, which was distinct from the prevalent TMUV Cluster 2 in duck flocks. To study the infectivity and pathogenicity of TMUV-GX in chickens and ducks, 7 day-old specific pathogen-free (SPF) chicks and SPF ducklings were infected with the same dose of the TMUV-GX. As a comparison, the duck-origin Cluster 2 strain, TMUV-JM, infection groups were set up in chicks and ducklings. Compared with the low infectivity and pathogenicity of TMUV-JM in chicks, the chicken-origin TMUV-GX displayed high replication competence in multiple tissues and caused tissues histopathological damage. In addition, the replication competence of TMUV-GX in ducklings was comparable to that of TMUV-JM. Our study revealed chicken-origin Cluster 3.2 TMUV exhibits high infectivity in chicks and ducklings, and suggested that chicken-origin Cluster 3.2 TMUV possesses a biological basis for widespread infection of chickens and ducks.
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