Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis.
Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis.
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DOI：
10.1016/j.bioactmat.2022.02.016
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发表时间：
2022-10
影响因子：
18.9
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Lei Y;Wang X;Liao J;Shen J;Li Y;Cai Z;Hu N;Luo X;Cui W;Huang W
在含有脂质体的水凝胶上形成的基于脂质的边界层可以促进润滑。然而，这些边界层可能被剪切破坏，导致润滑减少。在此，通过将塞来昔布（CLX）负载的脂质体并入基于动态共价键的透明质酸（HA）水凝胶（CLX@Lipo@HA-gel）中来产生剪切响应性边界润滑的载药水凝胶。动态交联网络使水凝胶能够响应剪切而重构，并且HA基质允许内部脂质体微贮库在滑动表面上积累，这导致形成边界层以提供稳定的润滑。此外，围绕水凝胶形成的水合壳可以延缓降解过程，从而有助于维持润滑。此外，体外和体内实验发现，CLX@Lipo@ HA-凝胶可以通过递送CLX和剪切响应性边界润滑来维持合成代谢-分解代谢平衡，减轻软骨磨损并减缓骨关节炎进展。总的来说，CLX@Lipo@ HA凝胶可以作为剪切响应边界润滑剂和药物递送载体，以减轻与摩擦相关的疾病，如骨关节炎。在这项研究中，氢化大豆磷脂酰胆碱（HSPC）脂质体纳入动态共价键为基础的透明质酸水凝胶，形成可注射的自我修复的水凝胶剪切响应边界润滑功能。这些水凝胶可以暴露表面上的内部脂质体微贮库，以通过剪切诱导的结构重排形成边界层，从而提供稳定的润滑。所构建的水凝胶可以在存在反复剪切和持续摩擦的生物医学应用中发挥作用。所构建的水凝胶可以通过递送塞来昔布来维持合成代谢-分解代谢平衡。所构建的水凝胶可作为生物润滑剂和递送载体用于治疗摩擦相关疾病。
Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) hydrogels (CLX@Lipo@HA-gel). The dynamic cross-linked network enables the hydrogel to get restructured in response to shear, and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces, which results in the formation of boundary layers to provide stable lubrication. Moreover, hydration shells formed surrounding the hydrogel can retard the degradation process, thus helping in sustaining lubrication. Furthermore, in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication. Overall, CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. In this study, hydrogenated soy phosphatidylcholine (HSPC) liposomes were incorporated within dynamic covalent bond-based hyaluronic acid hydrogels, forming injectable self-healing hydrogels with the function of shear-responsive boundary lubrication. These hydrogels can expose internal liposome microreservoirs on the surfaces to form boundary layers via shear-induced structural rearrangement, thus providing stable lubrication. The constructed hydrogels can be functional in biomedical applications where repeatedly shear and sustained friction exist. The constructed hydrogels can maintain anabolic-catabolic balance via delivering celecoxib. The constructed hydrogels can serve as biolubricants and delivery vehicles for the treatment of friction-related diseases.
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影响因子：
5.6
作者：
Hu Q;Ecker M
通讯作者：
Ecker M
影响因子：
5.5
作者：
Graham JM;Ayati BP;Ding L;Ramakrishnan PS;Martin JA
通讯作者：
Martin JA
DOI：
10.3390/ma13173851
发表时间：
2020-09-01
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Lopez Mora N;Owens M;Schmidt S;Silva AF;Bradley M
通讯作者：
Bradley M
影响因子：
29.4
作者：
Li, Lin;Yan, Bin;Zeng, Hongbo
通讯作者：
Zeng, Hongbo
影响因子：
7
作者：
Moon, S-J;Woo, Y. -J.;Min, J. -K.
通讯作者：
Min, J. -K.