CCR6 as a mediator of immunity in the lung and gut.
CCR6 as a mediator of immunity in the lung and gut.
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DOI：
10.1016/j.yexcr.2010.12.018
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发表时间：
2011-03-10
影响因子：
3.7
通讯作者：
Kunkel SL
中科院分区：
文献类型：
--
作者：
Ito T;Carson WF 4th;Cavassani KA;Connett JM;Kunkel SL
趋化因子是病原性损伤过程中白细胞募集的关键介质，在体内稳态中也起着重要作用。虽然大多数趋化因子受体都能与多种趋化因子结合，但CCR6的独特之处在于，它是为数不多的仅能与一种趋化因子配体CCL20结合的受体之一。CCR6是一种重要的受体，参与调节黏膜免疫的多个方面，包括介导未成熟树突状细胞(DC)和成熟树突状细胞(DC)的募集，以及专业抗原提呈细胞(APC)向上皮炎症部位的募集。此外，CCR6还介导了CD4+T(T-helper；Th)细胞和DC对肠道粘膜淋巴组织的归巢。树突状细胞是天然免疫和启动获得性免疫中必不可少的免疫细胞，在启动初级免疫应答中起着核心作用。本文在综述现有文献的基础上，对CCR6在肺和肠道上皮和粘膜部位的免疫应答中的作用进行了综述。
Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also play a prominent role in homeostasis. While most chemokine receptors bind to multiple chemokines, CCR6 is unique in that this receptor is one of only a few that can bind only a single chemokine ligand, CCL20. CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4+ T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue. DCs, which are known to be essential immune cells in innate immunity and in the initiation of adaptive immunity, play a central role in initiating a primary immune response Herein, we summarize the role of CCR6 in immune responses at epithelial and mucosal sites in both the lung and gut based on a review of the current literature.
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