Optical Imaging of Ionizing Radiation from Clinical Sources.
Optical Imaging of Ionizing Radiation from Clinical Sources.
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DOI：
10.2967/jnumed.116.178624
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Grimm J
中科院分区：
文献类型：
--
作者：
Shaffer TM;Drain CM;Grimm J
核医学利用电离辐射进行体内诊断和治疗。电离辐射来自多种来源，包括X射线、射线治疗、近距离放射治疗和各种注入的放射性核素。虽然正电子发射断层扫描和单光子发射计算机断层扫描仍然是临床上的支柱，但电离辐射的光学读数提供了许多好处，并补充了这些标准技术。此外，对于无法使用这些标准技术成像的电离辐射源，光学成像提供了一种独特的成像替代方案。本文通过辐射发光、切伦科夫发光和闪烁等机制对高能光子和带电粒子的放射性核素电离辐射和束流电离辐射的光学成像进行了综述。在治疗方面，这些可见光子已经在临床前与光动力学治疗剂相结合，以提高外部光源难以到达的深处的治疗反应。最后，综述了允许放射性核素单细胞光学成像的新的显微方法。
Nuclear medicine utilizes ionizing radiation for both in vivo diagnosis and therapy. Ionizing radiation comes from a variety of sources, including X-rays, beam therapy, brachytherapy, and various injected radionuclides. While positron emission tomography and single-photon emission computed tomography remain clinical mainstays, optical readouts of ionizing radiation offer numerous benefits and complement these standard techniques. Furthermore, for ionizing radiation sources that cannot be imaged using these standard techniques, optical imaging offers a unique imaging alternative. This article reviews optical imaging of both radionuclide- and beam-based ionizing radiation from high-energy photons and charged particles through mechanisms including radioluminescence, Cerenkov luminescence, and scintillation. Therapeutically, these visible photons have been combined with photodynamic therapeutic agents pre-clinically for increasing therapeutic response at depths difficult to reach with external light sources. Lastly, new microscopy methods that allow single cell optical imaging of radionuclides are reviewed.
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