Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease.
Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease.
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DOI：
10.1093/arclin/acaa109
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发表时间：
2021-07-19
期刊：
影响因子：
--
通讯作者：
Taylor KI
中科院分区：
文献类型：
--
作者：
Krumm S;Berres M;Kivisaari SL;Monsch AU;Reinhardt J;Blatow M;Kressig RW;Taylor KI
目的：语义记忆性能下降是已知的早期阿尔茨海默病（AD）的神经心理学标志，但最能预测疾病状态的任务格式是一个悬而未决的问题。本研究旨在确定语义流畅性任务和测量，以最好地区分早期AD患者（PATs）和认知健康对照。方法：对70名早期AD患者和67名认知健康的参与者进行动物、水果、工具和交通工具的语义流畅性评估。逻辑回归和接受者操作特征计算五总分语义流畅性测量。结果：与所有其他测量方法相比，生物（即正确动物总数+正确水果总数）的z统计量最高，曲线下面积最大，上下95%置信区间差最小。结论：生物全检是发现早期AD症状的有力工具。
Objective: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer’s disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. Method: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. Results: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. Conclusion: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
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影响因子：
5.7
作者：
Birn, Rasmus M.;Kenworthy, Lauren;Case, Laura;Caravella, Rachel;Jones, Tyler B.;Bandettin, Peter A.;Martin, Alex
通讯作者：
Martin, Alex
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
2.6
作者：
Hirni, Daniela I.;Kivisaari, Sasa L.;Taylor, Kirsten I.
通讯作者：
Taylor, Kirsten I.
影响因子：
3.6
作者：
Capitani, E;Laiacona, M;Barbarotto, R
通讯作者：
Barbarotto, R
影响因子：
2.6
作者：
Wright P;Randall B;Clarke A;Tyler LK
通讯作者：
Tyler LK