Structural insights into LINC complexes.
Structural insights into LINC complexes.
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DOI：
10.1016/j.sbi.2013.03.005
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发表时间：
2013-04
影响因子：
6.8
通讯作者：
Schwartz TU
中科院分区：
文献类型：
--
作者：
Sosa BA;Kutay U;Schwartz TU
Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. SUN-domain proteins spanning the inner nuclear membrane and KASH-peptide bearing proteins residing in the outer nuclear membrane directly bind and constitute the core of the LINC complex. These connections appear critical for a growing number of biological processes and aberrations are implicated in a host of diverse diseases, including muscular dystrophies, cardiomyopathies, and premature aging. We discuss recent developments in this vibrant research area, particularly in context of first structural insights into LINC complexes reported in the past year.
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影响因子：
64.5
作者：
Chikashige, Y;Tsutsumi, C;Hiraoka, Y
通讯作者：
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DOI：
10.1073/pnas.94.3.849
发表时间：
1997-02-04
影响因子：
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