FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia.
FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia.
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DOI：
10.1002/eji.200838516
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发表时间：
2008-11
影响因子：
5.4
通讯作者：
Davis, Randall S.
中科院分区：
文献类型：
--
作者：
Schreeder, Daniel M.;Pan, Jicun;Li, Fu Jun;Vivier, Eric;Davis, Randall S.
Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed that FCRL6 expression by NK and T cell subpopulations increases as a function of differentiation and is remarkably restricted to mature lymphocytes with cytotoxic capability. In particular, FCRL6 distinguishes perforin-expressing CD56dim NK cells, Vδ1+ and Vδ2+ γδ T cells, effector and effector memory CD8+ T cells, and rare cytotoxic CD4+ T cells in adult tissues. Analysis of this receptor in B cell chronic lymphocytic leukemia (CLL) was also performed. FCRL6 was found to mark significantly expanded populations of cytotoxic CD8+ T, CD4+ T, and NK cells in patients with CLL. Despite sequence homology with the known Fc receptors for IgG and IgE, FCRL6 did not bind immunoglobulin. Although FCRL6 can be tyrosine-phosphorylated, its antibody-mediated ligation was unable to influence cellular activation. Collectively these results demonstrate that FCRL6 is a distinct indicator of cytotoxic effector lymphocytes that is upregulated in diseases characterized by chronic immune stimulation.
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影响因子：
32.4
作者：
Hatzivassiliou, G;Miller, I;Dalla-Favera, R
通讯作者：
Dalla-Favera, R
影响因子：
20.3
作者：
Angelini, DF;Borsellino, G;Battistini, L
通讯作者：
Battistini, L
影响因子：
2.6
作者：
Scrivener, S;Goddard, RV;Prentice, AG
通讯作者：
Prentice, AG
DOI：
10.1084/jem.20052507
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Freud AG;Yokohama A;Becknell B;Lee MT;Mao HC;Ferketich AK;Caligiuri MA
通讯作者：
Caligiuri MA
影响因子：
15.3
作者：
Casazza, Joseph P.;Betts, Michael R.;Price, David A.;Precopio, Melissa L.;Ruff, Laura E.;Brenchley, Jason M.;Hill, Brenna J.;Roederer, Mario;Douek, Daniel C.;Koup, Richard A.
通讯作者：
Koup, Richard A.