IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection.
IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection.
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DOI：
10.1038/srep09223
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发表时间：
2015-03-18
影响因子：
4.6
通讯作者：
Dyrhol-Riise AM
中科院分区：
文献类型：
--
作者：
Tonby K;Ruhwald M;Kvale D;Dyrhol-Riise AM
结核病（TB）对人类发病率和死亡率有巨大影响，需要生物标志物来支持快速TB诊断并确保治疗启动和治愈，特别是在耐多药TB高发地区。从干血浆斑点（DPS）中分析的可溶性干扰素γ诱导蛋白10（IP-10）有可能作为TB感染的免疫诊断标志物。我们分析了IP-10的水平直接血浆和提取DPS平行ELISA从34个临床良好表征的结核病患者之前和整个24周的有效抗结核化疗。在治疗两周后，我们检测到血浆和DPS中IP-10水平的显著下降，测试之间具有良好的相关性。这在肺结核和肺外结核中都观察到。总之，血浆IP-10可以作为抗TB化疗反应的早期生物标志物，IP-10 DPS方法有可能发展成为用于资源有限环境的即时检测。必须进行进一步的研究来验证IP-10 DPS在结核病高流行国家的使用。
Tuberculosis (TB) has huge impact on human morbidity and mortality and biomarkers to support rapid TB diagnosis and ensure treatment initiation and cure are needed, especially in regions with high prevalence of multi-drug resistant TB. Soluble interferon gamma inducible protein 10 (IP-10) analyzed from dry plasma spots (DPS) has potential as an immunodiagnostic marker in TB infection. We analyzed IP-10 levels in plasma directly and extracted from DPS in parallel by ELISA from 34 clinically well characterized patients with TB disease before and throughout 24 weeks of effective anti-TB chemotherapy. We detected a significant decline of IP-10 levels in both plasma and DPS already after two weeks of therapy with good correlation between the tests. This was observed both in pulmonary and extrapulmonary TB. In conclusion, plasma IP-10 may serve as an early biomarker for anti-TB chemotherapy responses and the IP-10 DPS method has potential to be developed into a point-of care test for use in resource-limited settings. Further studies must be performed to validate the use of IP-10 DPS in TB high endemic countries.
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影响因子：
8.6
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
2012-06
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.tube.2011.02.006
发表时间：
2011-05
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
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作者：
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通讯作者：
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影响因子：
13.5
作者：
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通讯作者：
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