Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.
Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.
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DOI：
10.1002/hbm.23874
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Grossman M
中科院分区：
文献类型：
--
作者：
Phillips JS;Das SR;McMillan CT;Irwin DJ;Roll EE;Da Re F;Nasrallah IM;Wolk DA;Grossman M
成对螺旋丝tau蛋白的积累有助于阿尔茨海默病（AD）中的神经变性。18F-flortaucipir是一种对AD中tau蛋白敏感的正电子发射断层扫描（PET）放射性配体，但其临床应用将部分取决于其预测与选择性区域摄取相关的各种痴呆表型中认知症状的能力。我们在14名轻度受损患者（12名脑脊液分析物符合AD病理学）中检查了18F-氟陶西匹尔与认知之间的相关性，这些患者患有遗忘型（n=5）和非遗忘型AD综合征，包括后皮质萎缩（PCA，n=5）和逻辑减少变异型原发性进行性失语症（lvPPA，n=4）。遗忘型AD患者在记忆方面有缺陷; lvPPA在语言方面有缺陷;遗忘型AD和PCA患者在视觉空间功能方面都有缺陷。使用稀疏回归测试与认知的关联，并与解剖学感兴趣区域（ROI）中的关联进行比较。预计18F-flortaucipir摄取显示与每个域的区域特异性相关性。在多变量分析中，摄取升高，特别是与遗忘和非遗忘综合征相关的新皮质区。左前上级颞回的摄取占语言表现变异的67%。右舌回的摄取预测了85%的视觉空间表现的方差。通过右侧梭状回和楔叶以及包括右前海马和杏仁核的集群的摄取来预测记忆;该特征向量解释了患者评分中57%的方差。这些结果为18F-flortaucipir摄取、tau病理学和患者认知症状之间的关联提供了汇聚证据。
Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer’s disease (AD). 18F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between 18F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n=5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n=5) and logopenic-variant primary progressive aphasia (lvPPA, n=4). Amnestic AD patients had deficits in memory; lvPPA in language; and both amnestic AD and PCA patients in visuospatial function. Associations with cognition were tested using sparse regression and compared to associations in anatomical regions-of-interest (ROIs). 18F-flortaucipir uptake was expected to show regionally-specific correlations with each domain. In multivariate analyses, uptake was elevated in neocortical areas specifically associated with amnestic and non-amnestic syndromes. Uptake in left anterior superior temporal gyrus accounted for 67% of the variance in language performance. Uptake in right lingual gyrus predicted 85% of the variance in visuospatial performance. Memory was predicted by uptake in right fusiform gyrus and cuneus as well as a cluster comprising right anterior hippocampus and amygdala; this eigenvector explained 57% of the variance in patients’ scores. These results provide converging evidence for associations between 18F-flortaucipir uptake, tau pathology, and patients’ cognitive symptoms.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1093/brain/awt269
发表时间：
2013-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ahmed S;Haigh AM;de Jager CA;Garrard P
通讯作者：
Garrard P
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
9.9
作者：
Ash, Sharon;Evans, Emily;Grossman, Murray
通讯作者：
Grossman, Murray
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender