The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.
The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.
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DOI：
10.1111/imr.12163
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发表时间：
2014-05
影响因子：
8.7
通讯作者：
Malek TR
中科院分区：
文献类型：
--
作者：
Yuan X;Cheng G;Malek TR
CD4+叉头盒蛋白3（Foxp3）+调节性T细胞（TCR4）是介导外周中显性耐受的主要细胞类型。在过去的十年中，对TGFAP的广泛研究表明，这些细胞表达大量的异质性，以维持耐受性和调节免疫反应。Tactobacteria在其起源和发育过程、功能活动、迁移模式和激活状态方面具有异质性。用于产生特化T效应细胞的一些相同的环境线索和分子途径也被Tclad整合，以共定位和微调抑制机制，从而最佳地调节和抑制独特的自身和抗原特异性T细胞应答。本文就调节性T细胞异质性在维持外周免疫耐受中的意义作一综述。我们还强调了我们实验室最近的工作，该工作研究了表型不同Treg亚群彼此相关的程度，并以有序的方式扩展，以产生高度活化的短寿命Klrg1+抑制细胞，以优化免疫调节并维持Treg区室的稳态。
CD4+ Forkhead box protein 3 (Foxp3)+ regulatory T cells (Tregs) are the major cell type that mediates dominant tolerance in the periphery. Over the past decade, extensive study of Tregs has revealed that these cells express substantial heterogeneity to maintain tolerance and regulate immune responses. Tregs possess heterogeneity with respect to their origin and processes for development, functional activity, migratory pattern, and activation status. Some of the same environmental cues and molecular pathways utilized to generate specialized T-effector cells are also integrated by Tregs to co-localize and fine-tune suppressive mechanisms to optimally regulate and restrain distinctive self and antigen-specific T-cell responses. Here, we review our current understanding and significance of Treg heterogeneity in maintaining peripheral immune tolerance. We also highlight recent work from our laboratory that has studied the extent phenotypic distinct Treg subsets are related to each other and expand in an ordered fashion to give rise to highly activated short-lived Klrg1+ suppressor cells to optimize immune regulation and maintain homeostasis of the Treg compartment.
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影响因子：
3.7
作者：
Akimova T;Beier UH;Wang L;Levine MH;Hancock WW
通讯作者：
Hancock WW
影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
影响因子：
7.3
作者：
Beres AJ;Drobyski WR
通讯作者：
Drobyski WR
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.4049/jimmunol.1003961
发表时间：
2011-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castro I;Yu A;Dee MJ;Malek TR
通讯作者：
Malek TR