Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
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在这里，我们鉴定了一群组成型表达RORγt的骨髓中性粒细胞，它们可以产生IL-17 A（IL-17）并对其产生应答。IL-6、IL-23和RORγt，而不是T细胞或NK细胞，是中性粒细胞产生IL-17所必需的。IL-6和IL-23诱导中性粒细胞中IL-17 RC和Dectin-2的表达，并且IL-17 RC的表达通过曲霉菌和Dectin-2活化而增强。自分泌IL-17 A-IL-17受体活性诱导活性氧（ROS）的产生，并在体外和曲霉菌角膜炎模型中增加真菌杀伤。人中性粒细胞也表达RORγt，并在IL-6和IL-23刺激后诱导IL-17 A、IL-17 RC和Dectin-2表达。这些发现鉴定了一群表现出自分泌IL-17活性的人和鼠中性粒细胞，其可能有助于微生物和炎性疾病的病因学。
Here we identified a population of bone marrow neutrophils that constitutively express RORγt and which can produce and respond to IL-17A (IL-17). IL-6, IL-23 and RORγt, but not T cells or NK cells, are required for IL-17 production in neutrophils. IL-6 and IL-23 induced IL-17RC and Dectin-2 expression in neutrophils, and expression of IL-17RC was augmented by Aspergillus and Dectin-2 activation. Autocrine IL-17A–IL-17 receptor activity induced production of reactive oxygen species (ROS), and increased fungal killing in vitro and in a model of Aspergillus keratitis. Human neutrophils also expressed RORγt, and induced IL-17A, IL-17RC and Dectin-2 expression following IL-6 and IL-23 stimulation. These findings identify a population of human and murine neutrophils that exhibit autocrine IL-17 activity, and which likely contribute to the etiology of microbial and inflammatory diseases.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
3.7
作者：
Katayama M;Ohmura K;Yukawa N;Terao C;Hashimoto M;Yoshifuji H;Kawabata D;Fujii T;Iwakura Y;Mimori T
通讯作者：
Mimori T
DOI：
10.4049/jimmunol.1100123
发表时间：
2011-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lin AM;Rubin CJ;Khandpur R;Wang JY;Riblett M;Yalavarthi S;Villanueva EC;Shah P;Kaplan MJ;Bruce AT
通讯作者：
Bruce AT
DOI：
10.1084/jem.20080218
发表时间：
2008-07-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ma CS;Chew GY;Simpson N;Priyadarshi A;Wong M;Grimbacher B;Fulcher DA;Tangye SG;Cook MC
通讯作者：
Cook MC
影响因子：
4.4
作者：
Lalor, Stephen J.;Dungan, Lara S.;Mills, Kingston H. G.
通讯作者：
Mills, Kingston H. G.