Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
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胚胎淋巴结发育的位置由淋巴组织诱导细胞的初始聚集决定。我们证明，CXCL 13和CCL 21都吸引E12.5-E14.5淋巴组织诱导细胞，并且最初的聚集完全依赖于CXCL 13。视黄酸诱导的早期CXCL 13在基质组织细胞中的表达不依赖于光敏素信号传导。值得注意的是，邻近淋巴结原基的神经元表达视黄酸合成所必需的酶。此外，刺激成人的副渐近线神经输出导致肠道中CXCL 13的视黄酸受体依赖性诱导。因此，我们的数据表明，淋巴结发育的启动是由视黄酸介导的CXCL 13的表达控制，并表明视黄酸可能是由相邻的神经元提供。
Location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue inducer cells. We demonstrate that both CXCL13 and CCL21 attracted E12.5–E14.5 lymphoid tissue inducer cells and that initial clustering exclusively depended on CXCL13. Retinoic acid induced early CXCL13 expression in stromal organizer cells independent of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for retinoic acid synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to a retinoic acid receptor-dependent induction of CXCL13 in the gut. Therefore, our data show that initiation of lymph node development is controlled by retinoic acid-mediated expression of CXCL13 and suggest that retinoic acid may be provided by adjacent neurons.
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DOI：
10.1084/jem.20080039
发表时间：
2008-10-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hammerschmidt SI;Ahrendt M;Bode U;Wahl B;Kremmer E;Förster R;Pabst O
通讯作者：
Pabst O
DOI：
10.1084/jem.20021294
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Luther SA;Ansel KM;Cyster JG
通讯作者：
Cyster JG
影响因子：
4.8
作者：
Li, Y;Hashimoto, Y;Zhang, XK
通讯作者：
Zhang, XK
影响因子：
4.4
作者：
Mebius, RE;Miyamoto, T;Akashi, K
通讯作者：
Akashi, K
影响因子：
32.4
作者：
Meier, Dominik;Bornmann, Caroline;Finke, Daniela
通讯作者：
Finke, Daniela