Protein Degradation Systems as Antimalarial Therapeutic Targets.
Protein Degradation Systems as Antimalarial Therapeutic Targets.
复制标题
DOI：
10.1016/j.pt.2017.05.009
复制
发表时间：
2017-09
影响因子：
9.6
通讯作者：
Bogyo M
中科院分区：
文献类型：
--
作者：
Ng CL;Fidock DA;Bogyo M
Artemisinin (ART)-based combination therapies are the most efficacious treatment of non-complicated Plasmodium falciparum infection. Alarmingly, P. falciparum strains have acquired resistance to ART in Southeast Asia and Africa. ART creates widespread protein and lipid damage inside intra-erythrocytic parasites, necessitating macromolecule degradation. The proteasome is the main engine of Plasmodium protein degradation. Indeed, proteasome inhibition and ART synergized in ART-resistant parasites. Moreover, ubiquitin modification is associated with resistance to multiple antimalarials. Targeting the ubiquitin-proteasome system, therefore, is an attractive avenue to combat drug resistance. Here, we review recent advances leading to specific targeting of the Plasmodium proteasome. We also highlight the potential for targeting other non-proteasomal protein degradation systems as an additional strategy to disrupt protein homeostasis.
登录
查看更多内容
影响因子：
9.8
作者：
Bozdech, Zbynek;Llinas, Manuel;Pulliam, Brian Lee;Wong, Edith D;Zhu, Jingchun;DeRisi, Joseph L
通讯作者：
DeRisi, Joseph L
影响因子：
4.6
作者：
Borrmann S;Straimer J;Mwai L;Abdi A;Rippert A;Okombo J;Muriithi S;Sasi P;Kortok MM;Lowe B;Campino S;Assefa S;Auburn S;Manske M;Maslen G;Peshu N;Kwiatkowski DP;Marsh K;Nzila A;Clark TG
通讯作者：
Clark TG
影响因子：
3.6
作者：
Artavanis-Tsakonas, Katerina;Misaghi, Shahram;Ploegh, Hidde L.
通讯作者：
Ploegh, Hidde L.
影响因子：
46.9
作者：
Ghorbal, Mehdi;Gorman, Molly;Lopez-Rubio, Jose-Juan
通讯作者：
Lopez-Rubio, Jose-Juan
影响因子：
82.9
作者：
Brötz-Oesterhelt, H;Beyer, D;Labischinski, H
通讯作者：
Labischinski, H