Markers of cognitive reserve and dementia incidence in the English Longitudinal Study of Ageing.
Markers of cognitive reserve and dementia incidence in the English Longitudinal Study of Ageing.
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DOI：
10.1192/bjp.2020.54
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Cadar D
中科院分区：
文献类型：
--
作者：
Almeida-Meza P;Steptoe A;Cadar D
在目前人口老龄化的情况下，确定痴呆症的预防措施是当务之急。我们实施了认知储备(CR)标记物的多方面指数，并在具有代表性的英国人群样本中调查了15年来痴呆的发生率。数据来自英国老龄化纵向研究的12,280名年龄在50岁以上的参与者，他们的基线评估是第一波(2002-2003年)、第三波(2006-2007年)或第四波(2008-2009年)，没有患痴呆症，并一直跟踪到第八波(2016-2017)。使用标准化问卷构建了CR指数，作为教育、职业和休闲活动的综合衡量标准。用COX比例风险回归模型估计痴呆的危险比(HR)与CR水平(低、中、高)及其组成部分(教育、职业和休闲活动)有关。在随访期内，602名年龄在56岁至99岁之间的参与者患上了痴呆症。CR水平越高(HR为0.65，95%CI为0.48-0.89，p=0.008)，患痴呆症的风险越低。对其组成部分的个体分析显示，较高的教育水平(HR0.56，95%CI0.36-0.88，p=0.012)、职业(HR0.72，95%CI0.56-0.91，p=0.008)和休闲活动(HR0.74，95%CI0.56-0.99，p=0.047)预示着痴呆症风险的降低，前两个组成部分在较年轻的参与者(<；85岁)中尤其具有保护作用。这项研究表明，认知障碍水平较高的人患痴呆症的风险较低，表现为受过高等教育、复杂的职业和多方面的休闲活动。可通过英国数据服务(https://discover.ukdataservice.ac.uk).)获得
In the current climate of an ageing population, it is imperative to identify preventive measures for dementia. We implemented a multi-faceted index of cognitive reserve (CR) markers and investigated dementia incidence over 15 years of follow-up in a representative sample of the English population. Data were 12,280 participants aged 50+ from the English Longitudinal Study of Ageing, free from dementia at their baseline assessments being either wave 1 (2002–2003), 3 (2006–2007), or 4 (2008–2009), and followed up until wave 8 (2016–2017). CR index was constructed as a composite measure of education, occupation and leisure activities using a standardised questionnaire. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) of dementia in relation to CR levels (low, medium and high) and its components (education, occupation and leisure activities). During the follow-up period, 602 participants aged 56 to 99 developed dementia. Higher levels of CR (HR 0.65, 95% CI 0.48–0.89, p=0.008) were associated with a lower risk of dementia. An individual analysis of its components showed that higher levels of education (HR 0.56, 95% CI 0.36–0.88, p=0.012), occupation (HR 0.72, 95% CI 0.56–0.91, p=0.008) and leisure activities (HR 0.74, 95% CI 0.56–0.99, p=0.047) were predictive of a reduced dementia risk, with the first two components particularly protective in younger participants (<85 years old). This study showed a reduced risk of dementia for individuals with a higher level of CR, represented by higher education, complex occupations, and multifaceted level of leisure activities. Available via UK Data Services (https://discover.ukdataservice.ac.uk).
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影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
5.7
作者：
FRATIGLIONI, L;VIITANEN, M;WINBLAD, B
通讯作者：
WINBLAD, B
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4
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
Matthews, Fiona
影响因子：
6.9
作者：
JORM, AF
通讯作者：
JORM, AF