Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis.
Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis.
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DOI：
10.1002/art.38348
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发表时间：
2014-05
影响因子：
13.3
通讯作者：
O'Dell, James R.
中科院分区：
文献类型：
--
作者：
Mikuls, Ted R.;Payne, Jeffrey B.;Yu, Fang;Thiele, Geoffrey M.;Reynolds, Richard J.;Cannon, Grant W.;Markt, Jeffrey;McGowan, David;Kerr, Gail S.;Redman, Robert S.;Reimold, Andreas;Griffiths, Garth;Beatty, Mark;Gonzalez, Shawneen M.;Bergman, Debra A.;Hamilton, Bartlett C., III;Erickson, Alan R.;Sokolove, Jeremy;Robinson, William H.;Walker, Clay;Chandad, Fatiha;O'Dell, James R.
检查共同风险因素在多大程度上解释了牙周炎（PD）与类风湿性关节炎（RA）的关系，并检查PD和牙龈卟啉单胞菌（Pg）与疾病特征的相关性。RA病例（N=287）和对照组（N=330）进行了标准化的牙周检查。HLA-DRB 1状态使用来自扩展MHC的SNP进行插补。循环抗Pg抗体测定采用ELISA和龈下菌斑进行了评估，使用PCR的Pg的存在。使用多变量回归分析PD与RA的相关性。与对照组（26%）相比，RA（35%，p = 0.022）和aCCP阳性RA（n=240; 37%; p = 0.006）中PD更常见。抗-Pg或PCR检测Pg阳性频率与RA对照组无差异。抗Pg抗体与抗CCP抗体（r=0.14，p=0.022）和RF抗体（r=0.19，p=0.001）均显示出微弱但具有统计学显著性的相关性。PD与肿胀关节计数（p=0.004）、DAS-28-CRP（p=0.045）、总Sharp评分（p=0.015）、aCCP（p=0.011）和RF（p<0.001）增加相关。选择抗瓜氨酸肽抗体（ACPA;包括瓜氨酸聚丝蛋白抗体）在龈下Pg患者中较高，且无论是否吸烟，抗Pg抗体水平均较高。PD与确定的血清阳性RA的关联独立于检查的所有协变量，包括Pg感染的证据。PD和Pg似乎塑造RA相关的自身反应性。此外，PD表现出与确定的血清阳性RA的独立关系。
To examine the degree to which shared risk factors explain the relationship of periodontitis (PD) with rheumatoid arthritis (RA) and to examine associations of PD and Porphyomonas gingivalis (Pg) with disease features. RA cases (N=287) and controls (N=330) underwent a standardized periodontal examination. HLA-DRB1 status was imputed using SNPs from the extended MHC. Circulating anti-Pg antibody was measured using ELISA and subgingival plaque was assessed for the presence of Pg using PCR. Associations of PD with RA were examined using multivariable regression. PD was more common in RA (35%, p = 0.022) and aCCP positive RA (n=240; 37%; p = 0.006) vs. controls (26%). There were no RA-control differences in anti-Pg or the frequency of Pg positivity by PCR. Anti-Pg antibody showed weak but statistically significant associations with both anti-CCP (r=0.14, p=0.022) and RF (r=0.19, p=0.001). PD was associated with increased swollen joint counts (p=0.004), DAS-28-CRP (p=0.045), total Sharp scores (p=0.015), aCCP (p=0.011), and RF (p<0.001). Select anti-citrullinated peptide antibody (ACPA; including antibody to citrullinated filaggrin) were higher in patients with subgingival Pg and higher anti-Pg antibody levels irrespective of smoking. Associations of PD with established seropositive RA were independent of all covariates examined including evidence of Pg infection. Both PD and Pg appear to shape RA-related autoreactivity in RA. In addition, PD demonstrates an independent relationship with established seropositive RA.
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影响因子：
4.3
作者：
Genco, Robert J.;Falkner, Karen L.;Trevisan, Maurizio
通讯作者：
Trevisan, Maurizio
影响因子：
3.5
作者：
Harvey, G. P.;Fitzsimmons, T. R.;Bartold, P. M.
通讯作者：
Bartold, P. M.
DOI：
10.3899/jrheum.091398
发表时间：
2010-09
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Arkema EV;Karlson EW;Costenbader KH
通讯作者：
Costenbader KH
影响因子：
27.4
作者：
Hueber, Wolfgang;Tomooka, Beren H.;Robinson, William H.
通讯作者：
Robinson, William H.
影响因子：
3.9
作者：
Hitchon, Carol A.;Chandad, Fatiha;El-Gabalawy, Hani S.
通讯作者：
El-Gabalawy, Hani S.