Virus-based chemical and biological sensing.
Virus-based chemical and biological sensing.
复制标题
DOI：
10.1002/anie.200900231
复制
发表时间：
2009
影响因子：
16.6
通讯作者：
Cao, Binrui
中科院分区：
文献类型：
--
作者：
Mao, Chuanbin;Liu, Aihua;Cao, Binrui
病毒最近已被证明可用于检测目标分析物，如爆炸物，蛋白质，细菌，病毒，孢子和毒素具有高选择性和灵敏度。噬菌体（通常简称为噬菌体）是目前研究最多的病毒，主要是因为目标特异性非裂解性噬菌体（及其携带的肽和蛋白质）可以通过使用成熟的噬菌体展示技术进行鉴定，而裂解性噬菌体可以特异性地破坏细菌以释放细胞特异性标记分子，如可以测定的酶。此外，纳米材料具有良好的化学和热稳定性，可以与纳米材料结合并固定在分析装置中的换能器表面上。本文综述了在化学和生物传感器中结合传统分析技术使用荧光素所取得的进展。最近的进展中使用的病毒纳米材料复合材料和其他病毒在传感应用也突出。
Viruses have recently proven useful for the detection of target analytes such as explosives, proteins, bacteria, viruses, spores, and toxins with high selectivity and sensitivity. Bacteriophages (often shortened to phages), viruses that specifically infect bacteria, are currently the most studied viruses, mainly because target-specific nonlytic phages (and the peptides and proteins carried by them) can be identified by using the well-established phage display technique, and lytic phages can specifically break bacteria to release cell-specific marker molecules such as enzymes that can be assayed. In addition, phages have good chemical and thermal stability, and can be conjugated with nanomaterials and immobilized on a transducer surface in an analytical device. This Review focuses on progress made in the use of phages in chemical and biological sensors in combination with traditional analytical techniques. Recent progress in the use of virus—nanomaterial composites and other viruses in sensing applications is also high-lighted.
登录
查看更多内容
DOI：
10.1073/pnas.0403795101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Carrera, MRA;Kaufmann, GF;Janda, KD
通讯作者：
Janda, KD
影响因子：
3
作者：
Daly, SJ;Dillon, PP;O'Kennedy, R
通讯作者：
O'Kennedy, R
影响因子：
10.8
作者：
Chen, C;Daniel, MC;Dragnea, B
通讯作者：
Dragnea, B
影响因子：
6.6
作者：
Balci, S.;Bittner, A. M.;Kern, K.
通讯作者：
Kern, K.
影响因子：
9.3
作者：
Brigati, J;Williams, DD;Petrenko, VA
通讯作者：
Petrenko, VA