Laser Doppler vibrometry measurements of human cadaveric tympanic membrane vibration.
Laser Doppler vibrometry measurements of human cadaveric tympanic membrane vibration.
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DOI：
10.1186/1916-0216-42-17
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发表时间：
2013-02-25
期刊：
影响因子：
--
通讯作者：
Agrawal SK
中科院分区：
文献类型：
--
作者：
Beyea JA;Rohani SA;Ladak HM;Agrawal SK
确定在鼓膜上多个位置测量鼓膜振动以区分正常鼓膜与相关听骨病变的可行性。尸体人类颞骨研究。基础科学实验室。我们对四具尸体颞骨进行乳突切除和面隐入路，以在不破坏TM的情况下进入听骨。触诊听骨，以确保正常活动和完整的听骨链。然后对所有四个TMs进行激光多普勒振动测量（LDV）测量。在镫骨踏板固定、包括镫骨关节脱位和踝头固定后，在每个TM上重复LDV测量。LDV测量腰部、外踝侧突以及腰部四个象限的振动。最佳信噪比在2 ~ 4 kHz之间，在脐、前上象限、前下象限和后下象限。由于我们的目标是评估听骨链，我们选择了离听骨链最近的TM位置（内踝和外踝）进行进一步分析。正常与模拟听骨病变之间存在差异，但数值无统计学意义。LDV测量在技术上具有挑战性，需要优化才能获得一致的测量结果。本研究证明了LDV鉴别完整鼓膜后听骨病变的潜力。未来的研究将进一步确定这种诊断方式的临床作用。
To determine the feasibility of measuring tympanic membrane (TM) vibrations at multiple locations on the TM to differentiate normal eardrums from those with associated ossicular pathologies. Cadaveric human temporal bone study. Basic science laboratory. A mastoidectomy and facial recess approach was performed on four cadaveric temporal bones to obtain access to the ossicles without disrupting the TM. Ossicles were palpated to ensure normal mobility and an intact ossicular chain. Laser Doppler Vibrometry (LDV) measurements were then taken on all four TMs. LDV measurements were repeated on each TM following stapes footplate fixation, incudo-stapedial joint dislocation, and malleus head fixation. LDV measurements of TM vibration at the umbo, the lateral process of the malleus, and in each of the four quadrants of the TM. The best signal-to-noise ratios were found between 2 and 4 kHz, at the umbo, the anterior superior quadrant, the anterior inferior quadrant, and the posterior inferior quadrant. Since our goal was to assess the ossicular chain, we selected the TM locations closest to the ossicular chain (the umbo and lateral process of the malleus) for further analysis. Differences could be seen between normals and the simulated ossicular pathologies, but values were not statistically significant. LDV measurements are technically challenging and require optimization to obtain consistent measurements. This study demonstrates the potential of LDV to differentiate ossicular pathologies behind an intact tympanic membrane. Future studies will further characterize the clinical role of this diagnostic modality.
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DOI：
10.2310/7070.2007.0008
发表时间：
2007-04-01
期刊：
JOURNAL OF OTOLARYNGOLOGY
影响因子：
--
作者：
Bance, Manohar;Morris, David P.;Van Wijhe, Rene
通讯作者：
Van Wijhe, Rene
影响因子：
2.6
作者：
Arechvo, Irina;Lasurashvili, Nikoloz;Zahnert, Thomas
通讯作者：
Zahnert, Thomas
影响因子：
1.4
作者：
STASCHE, N;FOTH, HJ;HUTHOFF, C
通讯作者：
HUTHOFF, C
影响因子：
2.1
作者：
Rosowski, JJ;Mehta, RP;Merchant, SN
通讯作者：
Merchant, SN
影响因子：
1.6
作者：
Akache, F.;Funnell, W. R. J.;Daniel, S. J.
通讯作者：
Daniel, S. J.