Multivariate approach for longitudinal analysis of brain metabolite levels from ages 5-11 years in children with perinatal HIV infection.
Multivariate approach for longitudinal analysis of brain metabolite levels from ages 5-11 years in children with perinatal HIV infection.
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DOI：
10.1016/j.neuroimage.2021.118101
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发表时间：
2021-08-15
期刊：
影响因子：
5.7
通讯作者：
Little F
中科院分区：
文献类型：
--
作者：
van Biljon N;Robertson F;Holmes M;Cotton MF;Laughton B;van der Kouwe A;Meintjes E;Little F
治疗指南建议，围产期感染艾滋病毒（PHIV）的儿童在生命早期就开始抗逆转录病毒治疗（ART），并终身接受治疗。作为一项纵向研究的一部分，该研究旨在检查PHIV和早期ART对发育中的大脑的长期影响，89名PHIV儿童和85名未感染艾滋病毒的儿童（HIV -）对照组分别在5岁、7岁、9岁和11岁时接受了神经影像学检查，包括对三个大脑区域，即基底神经节（BG）、额中回灰质（MFGM）和三角区周围白质（PWM）进行单体素磁共振波谱（MRS）检查。我们使用一种传统上应用于生态数据的多元方法——相关响应模型（CRM）分析了绝对代谢物浓度随年龄的变化，并将这些结果与多层混合效应建模（MMEM）方法获得的结果进行了比较。两种方法在艾滋病毒感染状况以及年龄对纵向轨迹的影响方面都得出了相似的结果。两种方法都发现，在几乎所有区域的代谢物中，PHIV儿童和HIV -儿童都有类似的与年龄相关的增加。我们发现，与HIV -儿童相比，PHIV儿童在各个区域的GPC + PCh显著升高（在BG中95%置信区间=[0.033；0.105]；在PWM中95%置信区间=[0.021；0.099]；在MFGM中95%置信区间=[0.059；0.137]），并且在MFGM中的mI升高（95%置信区间=[0.131；0.407]）；此外，CRM模型还表明在BG中的mI升高（95%置信区间=[0.008；0.248]）。这些发现表明，尽管早期开始了ART治疗，但感染艾滋病毒的幼儿大脑仍存在持续的炎症。
Treatment guidelines recommend that children with perinatal HIV infection (PHIV) initiate antiretroviral therapy (ART) early in life and remain on it lifelong. As part of a longitudinal study examining the long-term consequences of PHIV and early ART on the developing brain, 89 PHIV children and a control group of 85 HIV uninfected children (HIV−) received neuroimaging at ages 5, 7, 9 and 11 years, including single voxel magnetic resonance spectroscopy (MRS) in three brain regions, namely the basal ganglia (BG), midfrontal gray matter (MFGM) and peritrigonal white matter (PWM). We analysed age-related changes in absolute metabolite concentrations using a multivariate approach traditionally applied to ecological data, the Correlated Response Model (CRM) and compared these to results obtained from a multilevel mixed effect modelling (MMEM) approach. Both approaches produce similar outcomes in relation to HIV status and age effects on longitudinal trajectories. Both methods found similar age-related increases in both PHIV and HIV− children in almost all metabolites across regions. We found significantly elevated GPC+PCh across regions (95% CI=[0.033; 0.105] in BG; 95% CI=[0.021; 0.099] in PWM; 95% CI= [0.059; 0.137] in MFGM) and elevated mI in MFGM (95% CI=[0.131; 0.407]) among children living with PHIV compared to HIV− children; additionally the CRM model also indicated elevated mI in BG (95% CI= [0.008; 0.248]). These findings suggest persistent inflammation across the brain in young children living with HIV despite early ART initiation.
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影响因子：
9.9
作者：
Keller, MA;Venkatraman, TN;Chang, L
通讯作者：
Chang, L
影响因子：
1.9
作者：
Govender, Rajeshree;Eley, Brian;Wilmshurst, Jo M.
通讯作者：
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影响因子：
9.9
作者：
BELMAN, AL;LANTOS, G;RUBINSTEIN, A
通讯作者：
RUBINSTEIN, A
DOI：
10.3174/ajnr.a4921
发表时间：
2016-12
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ackermann C;Andronikou S;Saleh MG;Laughton B;Alhamud AA;van der Kouwe A;Kidd M;Cotton MF;Meintjes EM
通讯作者：
Meintjes EM
影响因子：
3.3
作者：
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通讯作者：
Morrison, Leslie A.