Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans.
Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans.
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DOI：
10.3402/jom.v6.24878
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发表时间：
2014
影响因子：
4.5
通讯作者：
Burne RA
中科院分区：
文献类型：
--
作者：
Moye ZD;Zeng L;Burne RA
口腔和宿主行为的性质决定了口腔微生物区系的进化机制，以应对环境波动，特别是碳水化合物类型和可获得性的变化。在人类龋齿的情况下，过量碳水化合物的存在往往导致当地环境的改变，使其更有利于与疾病的发生和发展相关的物种，包括变形链球菌。了解致龋性物种如何对环境扰动做出反应的一些最早的努力是利用恒化器培养进行的，它提供了对培养条件和细菌行为的精细控制。基因组规模方法学的发展使复杂的培养技术与基因组水平的分析相结合，以更彻底地探索细菌病原体如何对环境刺激做出反应。最近对变形链球菌和其他密切相关的链球菌的研究已经开始揭示，碳水化合物代谢可以极大地影响致病潜力，并突出了营养获取对病原体成功的重要影响；口腔内外。总体而言，对致病性链球菌的研究已经开始揭示碳水化合物获取和分解代谢的仔细协调的基本本质，使微生物能够持久存在，并在条件允许的情况下引发或恶化疾病。
The nature of the oral cavity and host behaviors has mandated that the oral microbiota evolve mechanisms for coping with environmental fluctuations, especially changes in the type and availability of carbohydrates. In the case of human dental caries, the presence of excess carbohydrates is often responsible for altering the local environment to be more favorable for species associated with the initiation and progression of disease, including Streptococcus mutans. Some of the earliest endeavors to understand how cariogenic species respond to environmental perturbations were carried out using chemostat cultivation, which provides fine control over culture conditions and bacterial behaviors. The development of genome-scale methodologies has allowed for the combination of sophisticated cultivation technologies with genome-level analysis to more thoroughly probe how bacterial pathogens respond to environmental stimuli. Recent investigations in S. mutans and other closely related streptococci have begun to reveal that carbohydrate metabolism can drastically impact pathogenic potential and highlight the important influence that nutrient acquisition has on the success of pathogens; inside and outside of the oral cavity. Collectively, research into pathogenic streptococci, which have evolved in close association with the human host, has begun to unveil the essential nature of careful orchestration of carbohydrate acquisition and catabolism to allow the organisms to persist and, when conditions allow, initiate or worsen disease.
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影响因子：
3.2
作者：
BURNE, RA;SCHILLING, K;YASBIN, RE
通讯作者：
YASBIN, RE
影响因子：
3.2
作者：
Abranches, Jacqueline;Nascimento, Marcelle M.;Burne, Robert A.
通讯作者：
Burne, Robert A.
影响因子：
--
作者：
Burne, R A;Zeng, L;Nascimento, M M
通讯作者：
Nascimento, M M
影响因子：
4.2
作者：
BEIGHTON, D;RUSSELL, RRB;WHILEY, RA
通讯作者：
WHILEY, RA
影响因子：
3
作者：
CARLSSON, J;GRIFFITH, CJ
通讯作者：
GRIFFITH, CJ