Influence of serum cholesterol level and statin treatment on prostate cancer aggressiveness.
Influence of serum cholesterol level and statin treatment on prostate cancer aggressiveness.
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血清胆固醇水平和他汀类药物治疗对前列腺癌侵袭性的影响。
DOI：
10.18632/oncotarget.16943
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发表时间：
2017-07-18
期刊：
影响因子：
--
通讯作者：
Steinestel J
中科院分区：
文献类型：
--
作者：
Schnoeller TJ;Jentzmik F;Schrader AJ;Steinestel J
胆固醇水平和他汀类药物的使用都影响前列腺癌（PC）的发展和预后。在本回顾性横断分析三级转诊中心连续病例中，我们评估了767例组织学证实、临床局限性PC等待根治性前列腺切除术的高胆固醇血症（≥5.0mmol/l）、他汀类药物的使用和晚期/侵袭性PC之间的关系。我们发现HCE患者（n=287, 37.4%）低分化PC （Gleason评分≥7b， 81.1% vs. 4.9%）、局部肿瘤分期晚期（≥pT3, 57.7% vs. 22.2%）和淋巴结累及（19.8% vs. 1.6%）的发生率显著升高。多因素logistic回归分析确定高胆固醇血症是侵袭性和/或晚期PC的危险因素（or 2.01, p<0.001），而他汀类药物摄入的优势比为0.49 (p=0.005)，表明与高危PC呈负相关。尽管使用他汀类药物的患者数量有限（约9.5%），但经校正和加权的多因素logistic回归模型显示，术前高胆固醇血症与高危PC的诊断相关，而高危PC的诊断与他汀类药物的摄入有负相关。
Both cholesterol levels and the use of statins have been described to influence the development and prognosis of prostate cancer (PC). In this retrospective, cross-sectional analysis of consecutive cases from a tertiary referral center we evaluated an association between hypercholesterolemia (≥5.0mmol/l), the use of statins, and advanced/aggressive PC in 767 men with histologically confirmed, clinically localized PC awaiting radical prostatectomy. We found that patients with HCE (n=287, 37.4%) had a significantly higher incidence of poorly differentiated PC (Gleason score ≥7b, 81.1% vs. 4.9%), advanced local tumor stage (≥pT3, 57.7% vs. 22.2%), and nodal involvement (19.8% vs. 1.6%). Multivariate logistic regression analysis identified hypercholesterolemia as a risk factor for aggressive and/or advanced PC (OR 2.01, p<0.001) whereas statin intake showed an odds ratio of 0.49 (p=0.005) indicating a negative association with high-risk PC. Despite a limited number of patients using statins (~9.5%), adjusted and weighed multivariate logistic regression models revealed that preoperative hypercholesterolemia is associated with a diagnosis of high-risk PC which is negatively influenced by statin intake.
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影响因子：
4
作者：
Pelton, Kristine;Freeman, Michael R.;Solomon, Keith R.
通讯作者：
Solomon, Keith R.
影响因子：
2.3
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10.3
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