Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study.
Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study.
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DOI：
10.1007/s10552-010-9691-6
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发表时间：
2011-02
影响因子：
2.3
通讯作者：
Shipley, Martin J.
中科院分区：
文献类型：
--
作者：
Batty, G. David;Kivimaeki, Mika;Clarke, Robert;Smith, George Davey;Shipley, Martin J.
前列腺癌的决定因素——除了年龄增长、黑人种族和阳性家族史等已确定但不可改变的风险因素——知之甚少。在最初的白厅队列研究的40年随访中，我们检查了一系列基线社会经济、行为和代谢特征与前列腺癌死亡风险的关系，该研究导致17934名男性中有578人死于前列腺癌。在对一系列基线协变量进行调整后，比例风险回归分析的结果表明，婚姻状况（风险比；95%可信区间：丧偶/离婚vs已婚：1.44;0.95,2.18）、血胆固醇升高（3比1.35;1.11,1.65）和身材增加（3比1.37;1.09,1.74）与前列腺癌死亡相关，尽管在所有分析中，常规水平上的统计学意义并不明显。没有证据表明体育活动、吸烟习惯、社会经济地位、血压的任何组成部分或糖尿病可以预测这种恶性肿瘤的死亡风险。本研究提示，婚姻状况、血胆固醇和身高是前列腺癌死亡的危险指标。
The determinants of prostate cancer – aside from established but non-modifiable risk factors of increased age, black ethnicity and a positive family history – are poorly understood. We examined the association of a series of baseline socioeconomic, behavioural and metabolic characteristics with the risk of prostate cancer mortality in a 40 year follow-up of the original Whitehall cohort study which gave rise to 578 prostate cancer deaths in 17,934 men. After adjustment for a series of baseline covariates, results from proportional hazards regression analyses indicated that marital status (hazard ratio; 95% confidence interval: widowed/divorced vs. married: 1.44; 0.95, 2.18), raised blood cholesterol (tertile 3 vs. 1: 1.35; 1.11, 1.65), and increased physical stature (tertile 3 vs. 1: 1.37; 1.09, 1.74) were associated with death from prostate cancer, although statistical significance at conventional levels was not apparent in all analyses. There was no evidence that physical activity, smoking habit, socio-economic status, either component of blood pressure, nor diabetes predicted the risk of death from this malignancy herein. In the present study there was a suggestion that marital status, blood cholesterol and height were risk indices for death from prostate cancer.
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