Influenza A virus entry inhibitors targeting the hemagglutinin.
Influenza A virus entry inhibitors targeting the hemagglutinin.
复制标题
针对血凝素的甲型流感病毒进入抑制剂
DOI：
10.3390/v5010352
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发表时间：
2013-01-22
期刊：
影响因子：
--
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Yang J;Li M;Shen X;Liu S
Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.
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