Impact of age and sex on the composition and abundance of the intestinal microbiota in individuals with and without enteric infections.
Impact of age and sex on the composition and abundance of the intestinal microbiota in individuals with and without enteric infections.
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DOI：
10.1016/j.annepidem.2016.03.007
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发表时间：
2016-05
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
肠道微生物组对于人类健康和防止肠道病原体定植至关重要。尽管年龄和性别对肠道微生物的组成和丰度的影响尚不清楚，但患有和未患有肠道感染的个体的微生物群组成存在显着差异。对 200 名肠道感染患者和 75 名代表性别和多个年龄组的健康家庭成员的粪便 DNA 进行了比较 16S rRNA 基因测序研究。肠道感染患者及其健康家庭成员的微生物群落特征受到年龄和性别的影响。总体而言，我们观察到随着年龄的增长，拟杆菌丰度增加，而大肠杆菌丰度减少，尽管这些差异在肠道感染患者中最为明显。拟杆菌属在女性群体中也较高，而埃希氏菌在男性群体中占主导地位。由于大肠杆菌丰度先前与症状严重程度相关，因此肠道感染儿童可能最容易因大肠杆菌和拟杆菌丰度分别较高和较低而出现严重疾病结果。未来的研究应侧重于利用宏基因组学对微生物组的具体差异进行分类，并确定旨在将肠道微生物组转变为健康状态的新方法。
The intestinal microbiome is critical for human health and preventing colonization by enteric pathogens. There are notable differences in the microbiota composition among individuals with and without enteric infections, though the impact that age and gender has on the composition and abundance of intestinal microbes is not known. A comparative 16S rRNA gene sequencing study was performed on stool DNA from 200 patients with enteric infections and 75 healthy family members representing both sexes and multiple age groups. Microbial community profiles were affected by age and sex in patients with enteric infections and their healthy family members. Overall, we observed an increase in Bacteroides abundance and decrease in Escherichia abundance with age, though these differences were most apparent for patients with enteric infections. Genus Bacteroides was also higher in female communities while Escherichia predominated in males. Because Escherichia abundance was previously linked to symptom severity, children with enteric infections may be most susceptible to severe disease outcomes due to high and low abundance of Escherichia and Bacteroides, respectively. Future studies should focus on classifying specific differences in the microbiome using metagenomics and identifying novel methods aimed at shifting the intestinal microbiome to a healthy state.
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影响因子：
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作者：
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通讯作者：
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