Polycystic Ovary Syndrome: Important Underrecognised Cardiometabolic Risk Factor in Reproductive-Age Women.
Polycystic Ovary Syndrome: Important Underrecognised Cardiometabolic Risk Factor in Reproductive-Age Women.
复制标题
DOI：
10.1155/2015/786362
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Ougouag R
中科院分区：
文献类型：
--
作者：
Baldani DP;Skrgatic L;Ougouag R
多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病。虽然多囊卵巢综合征的诊断完全基于生殖标准，但它也是一种代谢紊乱。胰岛素抵抗、糖耐量受损、2型糖尿病、肥胖和血脂异常在多囊卵巢综合征女性中比在同龄无多囊卵巢综合征女性中更常见。在多囊卵巢综合征中表现出的许多代谢异常由于同时发生的肥胖而恶化。然而，即使在患有多囊卵巢综合征的瘦女性中也会出现一些代谢紊乱，因此，我们有理由认为这是多囊卵巢综合征的内在原因。本文就产生这些代谢紊乱的内在因素作一综述。肥胖和其他代谢异常的后果也进行了讨论。多囊卵巢综合征患者的代谢紊乱导致慢性低度炎症和心血管损伤，从而增加患心血管疾病的风险。尽管许多研究表明PCOS女性心血管疾病的替代生物标志物升高，但尚不清楚这种升高在多大程度上和程度上促成了更频繁和更早的事件。
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more common in women with PCOS than in age-comparable women without PCOS. Many of the metabolic abnormalities that manifest in PCOS are worsened by the concurrent incidence of obesity. However, some of these metabolic perturbations occur even in lean women with PCOS and therefore are rightfully recognized as intrinsic to PCOS. The intrinsic factors that produce these metabolic disturbances are reviewed in this paper. The consequences of obesity and the other metabolic aberrations are also discussed. The metabolic perturbations in PCOS patients lead to chronic low-grade inflammation and to cardiovascular impairments that heighten the risk of having cardiovascular disease. Even though many studies have shown an elevation in surrogate biomarkers of cardiovascular disease in PCOS women, it is still not clear to what extent and magnitude the elevation precipitates more frequent and earlier events.
登录
查看更多内容
影响因子：
6.1
作者：
Carmina, E;Legro, RS;Lobo, RA
通讯作者：
Lobo, RA
影响因子：
5.8
作者：
Barber, Thomas M.;Golding, Stephen J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
5.8
作者：
Carmina, E;Napoli, N;Lobo, RA
通讯作者：
Lobo, RA
影响因子：
5.8
作者：
Brzechffa, PR;Jakimiuk, AJ;Magoffin, DA
通讯作者：
Magoffin, DA
影响因子：
5.8
作者：
Barber, Thomas M.;Casanueva, Felipe F.;Wass, John A. H.
通讯作者：
Wass, John A. H.