Treatment of cytomegalovirus retinopathy with ganciclovir.
Treatment of cytomegalovirus retinopathy with ganciclovir.
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用更昔洛韦治疗巨细胞病毒视网膜病。
DOI：
10.1016/s0161-6420(87)33534-1
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发表时间：
1987
期刊：
影响因子：
13.7
通讯作者：
J. Cherry
中科院分区：
文献类型：
--
作者：
G. Holland;G. Holland;Y. Sidikaro;Y. Sidikaro;A. Kreiger;A. Kreiger;D. Hardy;M. Sakamoto;M. Sakamoto;L. Frenkel;D. Winston;M. Gottlieb;Y. Bryson;R. Champlin;W. Ho;R. E. Winters;P. Wolfe;J. Cherry
更昔洛韦是一种实验性抗病毒药物，具有抗人巨细胞病毒（CMV）的活性。40例获得性免疫缺陷综合征（AIDS）和巨细胞病毒视网膜病变患者在同情方案的基础上用更昔洛韦治疗。初始治疗剂量为5.0至14.0 mg/kg/天，持续9至26天。药物反应的迹象是病变停止扩大，视网膜组织混浊减少，出血和血管炎消退。88%的患者完全缓解，9%的患者不完全缓解。88%的患者视力改善或保持稳定。最初的治疗并没有根除眼睛里的活病毒。为了防止疾病再次激活，26例患者接受低剂量维持治疗，范围为1.5至7.5 mg/kg/天，每天1次或2次，每周3至7天。在接受持续、不间断维持治疗超过3周的患者中，有50%的患者出现了未知原因的疾病再激活。30%接受初始治疗的患者和38%接受维持治疗的患者出现了需要停止治疗的可逆性中性粒细胞减少症。孔源性视网膜脱离是7例患者的晚期并发症。通过减少或延缓视力丧失，更昔洛韦似乎对艾滋病患者CMV视网膜病变的治疗有用。
Ganciclovir is an experimental antiviral drug with activity against human cytomegalovirus (CMV). Forty patients with acquired immune deficiency syndrome (AIDS) and CMV retinopathy were treated with ganciclovir on a compassionate protocol basis. Initial treatment doses ranged from 5.0 to 14.0 mg/kg/day for 9 to 26 days. Signs of drug response were a halt to enlargement of lesions, decreased opacification of retinal tissue, and resolution of hemorrhage and vasculitis. Complete response was seen in 88% of patients and incomplete response was seen in 9%. Vision improved or remained stable in 88% of patients. Initial treatment did not eradicate live virus from the eye. To prevent reactivation of disease, 26 patients received low-dose maintenance therapy ranging from 1.5 to 7.5 mg/kg/day, once or twice daily, 3 to 7 days per week. Reactivation of disease developed for unknown reasons in 50% of patients on continuous, uninterrupted maintenance therapy for longer than 3 weeks. Reversible neutropenia, requiring cessation of treatment, developed in 30% of patients on initial treatment and in 38% of patients on maintenance therapy. Rhegmatogenous retinal detachment was a late complication in seven patients. By reducing or delaying visual loss, ganciclovir appears to be useful in the management of CMV retinopathy in patients with AIDS.
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影响因子：
13.7
作者：
Pepose,JS;Holland,GN;Nestor,MS;Cochran,AJ;Foos,RY
通讯作者：
Foos,RY
获得性免疫缺陷综合征的视网膜病变。
DOI：
--
发表时间：
1984
期刊：
Transactions of the American Ophthalmological Society
影响因子：
--
作者：
Friedman,AH
通讯作者：
Friedman,AH
9-[2-羟基-1-(羟甲基)乙氧基甲基]鸟嘌呤治疗巨细胞病毒肺炎的活性。
影响因子：
39.2
作者：
Shepp,DH;Dandliker,PS;deMiranda,P;Burnette,TC;Cederberg,DM;Kirk,LE;Meyers,JD
通讯作者：
Meyers,JD
影响因子：
13.7
作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
通讯作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
DOI：
10.1073/pnas.80.9.2767
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHENG, YC;HUANG, ES;GRILL, SP
通讯作者：
GRILL, SP