Tumour vascularization: sprouting angiogenesis and beyond.
Tumour vascularization: sprouting angiogenesis and beyond.
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DOI：
10.1007/s10555-007-9094-7
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发表时间：
2007-12
期刊：
影响因子：
--
通讯作者：
Griffioen AW
中科院分区：
文献类型：
--
作者：
Hillen F;Griffioen AW
肿瘤血管生成是肿瘤生物学中一个快速发展的领域。许多生长因素和机制已经被解开。近30年来，新血管从现有血管中发芽被认为是肿瘤血管化的唯一方式。然而，在过去几年中，已经确定了几个额外的机制。随着肠套管血管生成、内皮祖细胞募集、血管共选、血管生成模拟和淋巴管生成对肿瘤生长的贡献的发现，抗肿瘤靶向策略将比最初想象的更加复杂。这篇综述强调了这些过程和干预措施在癌症治疗中的潜在应用。因此，基于多模式抗血管生成、抗血管生成模拟和抗淋巴管生成策略，未来的抗血管治疗可能是最有益的。
Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of existing ones was considered as an exclusive way of tumour vascularisation. However, over the last years several additional mechanisms have been identified. With the discovery of the contribution of intussusceptive angiogenesis, recruitment of endothelial progenitor cells, vessel co-option, vasculogenic mimicry and lymphangiogenesis to tumour growth, anti-tumour targeting strategies will be more complex than initially thought. This review highlights these processes and intervention as a potential application in cancer therapy. It is concluded that future anti-vascular therapies might be most beneficial when based on multimodal anti-angiogenic, anti-vasculogenic mimicry and anti-lymphangiogenic strategies.
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