Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder.
Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder.
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患有强迫症的儿童和青少年的一级亲属的精神疾病。
DOI：
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发表时间：
1990
影响因子：
13.3
通讯作者：
J. Rapoport
中科院分区：
文献类型：
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作者：
M. Lenane;S. Swedo;H. Leonard;D. Pauls;W. Sceery;J. Rapoport
对 46 名患有严重原发性强迫症 (OCD) 的儿童和青少年的 145 名一级亲属（89 名父母 [96%] 和 56 名兄弟姐妹 [98%]）进行了临床和结构化精神病学访谈。家长访谈由对先证者诊断不知情的评估者进行评分。 30% 的先证者至少有一名一级亲属患有强迫症：25% 的父亲和 9% 的母亲被诊断为强迫症。 45% 的父亲和 65% 的母亲曾接受过一项或多项其他精神病学诊断。强迫症的家族发病率高于一般人群的预期，也高于行为障碍患者父母的发病率，这与强迫症的遗传因素是一致的。先证者及其父母表现出的强迫症状通常是不同的，反对任何简单的社会或文化传播。
One hundred and forty-five first-degree relatives (89 parents [96%] and 56 siblings [98%]) of 46 children and adolescents with severe primary obsessive compulsive disorder (OCD) were personally interviewed with clinical and structured psychiatric interviews. Parent interviews were scored by a rater blind to proband diagnosis. Thirty percent of probands had at least one first-degree relative with OCD: 25% of fathers and 9% of mothers received this diagnosis. Forty-five percent of fathers and 65% of mothers received one or more other psychiatric diagnoses. The increased familial rate of OCD over that expected from a general population, and over that found in parents of conduct disordered patients, is consistent with a genetic factor in OCD. Presenting obsessive compulsive symptoms of probands and their parents were usually dissimilar, arguing against any simple social or cultural transmission.
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影响因子：
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作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
家族史方法与直接访谈的比较。
影响因子：
6.6
作者：
Orvaschel,H;Thompson,WD;Belanger,A;Prusoff,BA;Kidd,KK
通讯作者：
Kidd,KK
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
用氯米帕明和地昔帕明治疗儿童和青少年的强迫症。
影响因子：
--
作者：
Leonard,HL;Swedo,SE;Rapoport,JL;Koby,EV;Lenane,MC;Cheslow,DL;Hamburger,SD
通讯作者：
Hamburger,SD