Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.
Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.
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DOI：
10.1002/acr.20071
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发表时间：
2010-02
影响因子：
4.7
通讯作者：
Feldman, Brian M.
中科院分区：
文献类型：
--
作者：
Huber, Adam M.;Giannini, Edward H.;Bowyer, Suzanne L.;Kim, Susan;Lang, Bianca;Lindsley, Carol B.;Pachman, Lauren M.;Pilkington, Clarissa;Reed, Ann M.;Rennebohm, Robert M.;Rider, Lisa G.;Wallace, Carol A.;Feldman, Brian M.
利用青少年皮肌炎（JDM）的调查数据和专家意见，制定少数共识的治疗方案，反映目前的中重度JDM的初始治疗。2007年1- 2月1日至2日在加拿大安大略的多伦多举行了一次协商一致会议。名义组技术用于达成共识的治疗方案，代表典型的管理中重度JDM。还就这些方案适用于哪些患者（入选和排除标准）、在启动这些方案之一之前应进行的初步研究、应收集以评价这些方案的数据、需要或建议的伴随干预达成了共识。制定了三个方案，描述了治疗的前2个月。所有方案均包括皮质类固醇和甲氨蝶呤。一种方案还包括静脉注射丙种球蛋白。会议参与者讨论的所有问题都达成了共识，尽管存在一些争议。这项研究表明，尽管临床实践存在相当大的差异，但对JDM的初始治疗达成共识是可能的。一旦这些方案延长超过2个月，这些方案将可用于临床。通过使用考虑患者差异（适应症混淆）的方法，评价方案的比较有效性。在未来，目标将是确定中重度JDM的最佳治疗方法。
To use juvenile dermatomyositis (JDM) survey data and expert opinion to develop a small number of consensus treatment protocols which reflect current initial treatment of moderately severe JDM. A consensus meeting was held in Toronto, Ontario, Canada on December 1-2, 2007. Nominal group technique was used to achieve consensus on treatment protocols which represented typical management of moderately severe JDM. Consensus was also reached on which patients these protocols would be applicable to (inclusion and exclusion criteria), initial investigations which should be done prior to initiating one of these protocols, data which should be collected to evaluate these protocols, concomitant interventions that would be required or recommended. Three protocols were developed which described the first 2 months of treatment. All protocols included corticosteroids and methotrexate. One protocol also included intravenous gammaglobulin. Consensus was achieved for all issues that were addressed by conference participants, although there were some areas of controversy This study shows that it is possible to achieve consensus on the initial treatment of JDM, despite considerable variation in clinical practice. Once these protocols are extended beyond 2 months, these protocols will be available for clinical use. By using methods which account for differences between patients (confounding by indication), the comparative effectiveness of the protocols will be evaluated. In the future, the goal will be to identify the optimal treatment of moderately severe JDM.
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DOI：
10.1002/art.23340
发表时间：
2008-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Huber, Adam M.;Dugan, Elizabeth M.;Rider, Lisa G.
通讯作者：
Rider, Lisa G.
影响因子：
10.7
作者：
HORTON, JN
通讯作者：
HORTON, JN
影响因子：
5.1
作者：
BITNUM, S;HOPPS, HC;TRAVIS, LB
通讯作者：
TRAVIS, LB
影响因子：
7.2
作者：
Pullenayegum, Eleanor M.;Lam, Catherine;Feldman, Brian M.
通讯作者：
Feldman, Brian M.
DOI：
10.1002/art.11122
发表时间：
2003-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Mendez, EP;Lipton, R;Pachman, LM
通讯作者：
Pachman, LM