Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin.
Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin.
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DOI：
10.1111/bjd.20955
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发表时间：
2022-05
影响因子：
10.3
通讯作者：
Cork, Michael J.
中科院分区：
文献类型：
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作者：
Danby, Simon G.;Andrew, Paul, V;Kay, Linda J.;Pinnock, Abigail;Chittock, John;Brown, Kirsty;Williams, Samuel F.;Cork, Michael J.
特应性皮炎患者的皮肤特征在于角质层脂质水平异常。因此，层状基质被破坏，皮肤屏障功能减弱，增加了皮肤对刺激物和过敏原的敏感性。确定含有神经酰胺、甘油三酯和胆固醇的多泡乳剂是否可以增强皮肤屏障并防止皮肤刺激。在34名患有干燥、湿疹倾向性皮肤的成人中进行了一项随机、观察者盲、患者内对照研究。每个参与者在一个前臂和小腿上用测试霜治疗4周，在另一个前臂和小腿上用参考润肤霜治疗。在治疗前后测定皮肤性质。使用新型界面通过傅里叶变换红外光谱法评估脂质结构。在用试验乳膏处理的部位，皮肤屏障完整性更高[经表皮水分损失曲线下面积的效应量为-162，95%置信区间（CI）为-206至-118]。与参比品相比，皮肤对十二烷基硫酸钠的敏感性降低（-0.5分可见发红，97.57% CI-1.00至-0.25），经表皮水分丢失也降低（-15.3 g m-2 h-1，95% CI-20.3至-10.4）。用测试霜治疗的部位显示出脂质链有序性增强，这与皮肤屏障完整性显着相关（r = 0·61）。与参比品相比，试验乳膏治疗增加了水合作用（8.61电容单位，95% CI 6.61 - 10.6），并减少了干燥迹象。该测试霜有助于皮肤屏障的恢复，并保护皮肤免受干燥和刺激。与英国常用的处方润肤剂相比，测试霜非常适合干燥，敏感皮肤的管理。 链接评论：A.C.肯德尔和A.尼古拉。英国皮肤病学杂志2022; 186：764-765。 在线提供简明语言摘要
The skin of patients with atopic dermatitis is characterized by abnormal stratum corneum lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished, increasing skin sensitivity to irritants and allergens. To determine whether a cream containing ceramides, triglycerides and cholesterol in a multivesicular emulsion can reinforce the skin barrier and protect against skin irritation. A randomized observer‐blind intrapatient‐controlled study in 34 adults with dry, eczema‐prone skin was conducted. Each participant underwent 4 weeks of treatment with the test cream on one forearm and lower leg and a reference emollient cream on the other. Skin properties were determined before and after treatment. Lipid structure was assessed by Fourier‐transform infrared spectroscopy using a novel interface. Skin barrier integrity was greater at sites treated with the test cream [effect size for area under the transepidermal water loss curve −162, 95% confidence interval (CI) −206 to −118]. Skin sensitivity to sodium lauryl sulfate was reduced (−0·5 points visual redness, 97·57% CI −1·00 to −0·25), as was transepidermal water loss (−15·3 g m−2 h−1, 95% CI −20·3 to −10·4) compared with the reference. Sites treated with the test cream displayed enhanced lipid chain ordering, which was significantly associated with skin barrier integrity (r = 0·61). Compared with the reference, treatment with the test cream increased hydration (8·61 capacitance units, 95% CI 6·61–10·6) and decreased signs of dryness. The test cream facilitates skin barrier restoration and protects the skin from dryness and irritation. Compared with a commonly prescribed emollient in the UK, the test cream is highly suited to the management of dry, sensitive skin. Linked Comment: A.C. Kendall and A. Nicolaou. Br J Dermatol 2022; 186:764–765. Plain language summary available online
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影响因子：
6.5
作者：
Janssens, Michelle;van Smeden, Jeroen;Bouwstra, Joke A.
通讯作者：
Bouwstra, Joke A.
影响因子：
17.1
作者：
Leung DYM;Calatroni A;Zaramela LS;LeBeau PK;Dyjack N;Brar K;David G;Johnson K;Leung S;Ramirez-Gama M;Liang B;Rios C;Montgomery MT;Richers BN;Hall CF;Norquest KA;Jung J;Bronova I;Kreimer S;Talbot CC Jr;Crumrine D;Cole RN;Elias P;Zengler K;Seibold MA;Berdyshev E;Goleva E
通讯作者：
Goleva E
影响因子：
1.5
作者：
Draelos, Zoe D.;Baalbaki, Nada H.;Colon, Gene
通讯作者：
Colon, Gene
影响因子：
--
作者：
MAN, MQ;FEINGOLD, KR;ELIAS, PM
通讯作者：
ELIAS, PM
DOI：
10.1159/000049396
发表时间：
2002-03-01
期刊：
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
影响因子：
--
作者：
Billmann-Eberwein, C;Rippke, F;Krutmann, J
通讯作者：
Krutmann, J