Exercise training alters the genomic response to acute exercise in human adipose tissue.
Exercise training alters the genomic response to acute exercise in human adipose tissue.
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DOI：
10.2217/epi-2018-0039
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发表时间：
2018-08
期刊：
影响因子：
3.8
通讯作者：
Barrès R
中科院分区：
文献类型：
--
作者：
Fabre O;Ingerslev LR;Garde C;Donkin I;Simar D;Barrès R
确定脂肪组织对急性和慢性运动作出反应的基因组机制。我们分析了在耐力训练前后收集的人类脂肪组织对急性运动的转录和表观遗传学反应。虽然急性运动是在相同的相对强度下进行的，但耐力训练降低了急性运动后转录变化的幅度。急性运动引起的DNA甲基化重塑在训练状态下比未训练状态下更为显著。我们发现训练前的32个基因和训练后的6个基因在急性运动后的基因表达和DNA甲基化变化之间存在重叠，特别是在脂肪细胞特异性基因上。训练状态不同地影响人类脂肪组织对急性运动的表观遗传和转录反应。
To determine the genomic mechanisms by which adipose tissue responds to acute and chronic exercise. We profiled the transcriptomic and epigenetic response to acute exercise in human adipose tissue collected before and after endurance training. Although acute exercises were performed at same relative intensities, the magnitude of transcriptomic changes after acute exercise was reduced by endurance training. DNA methylation remodeling induced by acute exercise was more prominent in trained versus untrained state. We found an overlap between gene expression and DNA methylation changes after acute exercise for 32 genes pre-training and six post-training, notably at adipocyte-specific genes. Training status differentially affects the epigenetic and transcriptomic response to acute exercise in human adipose tissue.
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