Efficacy and safety of curcumin in diabetic retinopathy: A protocol for systematic review and meta-analysis.
Efficacy and safety of curcumin in diabetic retinopathy: A protocol for systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0282866
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
糖尿病视网膜病变（DR）是糖尿病最常见的并发症之一，已成为全球主要的致盲原因。姜黄素是姜黄（姜黄）的提取物，可有效预防和治疗糖尿病。最近的研究表明，姜黄素可以延缓DR的发展。本研究将对目前发表的姜黄素治疗DR患者的随机对照试验（RCT）进行系统评价和荟萃分析，以评估其疗效和安全性。我们将在PubMed、Medline、EMBASE、科克伦图书馆、中国知网（CNKI）、维普、万方数据库中检索姜黄素治疗DR的相关研究，检索时间从各自的起始日期至2022年5月。将对从合格的随机对照试验中提取的数据进行荟萃分析，包括DR的进展、视力、视野、黄斑水肿、生活质量和不良事件。将使用Review Manager 5.4.1软件进行荟萃分析，结果将基于随机效应或固定效应模型，具体取决于异质性。建议、开发和评价分级（GRADE）系统将用于评价证据的可靠性和质量。本研究的结果将为姜黄素治疗DR的有效性和安全性提供可靠和高质量的证据，本研究将是第一个全面评估姜黄素治疗DR的有效性和安全性的荟萃分析，并将为该疾病的临床管理提供有用的证据。INPLASY202250002。
Diabetic retinopathy (DR) is one of the most common complications of diabetes and has become a major global cause of blindness. Curcumin, an extract of Curcuma longa (turmeric), is effective in preventing and treating diabetes. Recent studies have shown that curcumin can delay DR development. However, there has been no systematic review of its treatment of DR. This study will conduct a systematic review and meta-analysis of currently published randomized controlled trials (RCT) of curcumin for treating DR patients to evaluate its efficacy and safety. We will search the relevant studies of curcumin in the treatment of DR in PubMed, Medline, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases from their respective inception dates to May 2022. A meta-analysis of the data extracted from qualified RCTs will be conducted, including the progression of DR, visual acuity, visual field, macular edema, quality of life, and adverse events. The meta-analysis will be performed using Review Manager 5.4.1 software, and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence. The results of this study will provide sound and high-quality evidence for the efficacy and safety of curcumin in the treatment of DR. This study will be the first meta-analysis to comprehensively assess the efficacy and safety of curcumin in the treatment of DR and will provide helpful evidence for the clinical management of this disease. INPLASY202250002.
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视网膜疾病中的姜黄素：从长凳到床边的全面评论。
影响因子：
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作者：
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