Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma.
Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma.
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长非编码RNA在口腔鳞状细胞癌转移中的作用
DOI：
10.3389/fonc.2020.616717
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发表时间：
2020
影响因子：
4.7
通讯作者：
Shang Z
中科院分区：
文献类型：
--
作者：
Xu Y;Jiang E;Shao Z;Shang Z
口腔鳞状细胞癌(OSCC)是世界范围内常见的恶性肿瘤。转移是口腔鳞癌患者死亡的主要原因。长非编码RNA(Long Non Coding RNAs，LncRNAs)是影响口腔鳞癌转移的关键因素之一，是长度超过200个核苷酸的RNA的一种亚型，几乎没有编码潜能。近年来，lncRNAs在染色质修饰、转录调控、RNA稳定性调节、mRNA翻译等生物学过程中的重要作用逐渐被揭示。越来越多的研究表明，lncRNAs可以在表观遗传、转录和转录后水平上调控包括口腔鳞癌在内的多种肿瘤的转移。本文主要讨论了lncRNAs在口腔鳞癌转移中的作用及其可能的机制。大多数lncRNAs起癌基因的作用，只有少数lncRNAs能抑制口腔鳞癌的转移。此外，我们还简要介绍了肿瘤相关成纤维细胞相关的lncRNAs在口腔鳞癌转移中的研究现状。最后，对LncRNAs介导的口腔鳞癌细胞与肿瘤微环境之间的串扰在口腔鳞癌转移中的研究前景进行了讨论，特别是对外体和淋巴管生成的潜在研究价值进行了讨论。总的来说，lncRNAs有望用于口腔鳞癌转移的筛查、治疗和预后监测，但要更好地了解lncRNAs的生物学功能还需要做更多的工作。
Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Metastasis is the main cause of the death of OSCC patients. Long noncoding RNAs (lncRNAs), one of the key factors affecting OSCC metastasis, are a subtype of RNA with a length of more than 200 nucleotides that has little or no coding potential. In recent years, the important role played by lncRNAs in biological processes, such as chromatin modification, transcription regulation, RNA stability regulation, and mRNA translation, has been gradually revealed. More and more studies have shown that lncRNAs can regulate the metastasis of various tumors including OSCC at epigenetic, transcriptional, and post-transcriptional levels. In this review, we mainly discussed the role and possible mechanisms of lncRNAs in OSCC metastasis. Most lncRNAs act as oncogenes and only a few lncRNAs have been shown to inhibit OSCC metastasis. Besides, we briefly introduced the research status of cancer-associated fibroblasts-related lncRNAs in OSCC metastasis. Finally, we discussed the research prospects of lncRNAs-mediated crosstalk between OSCC cells and the tumor microenvironment in OSCC metastasis, especially the potential research value of exosomes and lymphangiogenesis. In general, lncRNAs are expected to be used for screening, treatment, and prognosis monitoring of OSCC metastasis, but more work is still required to better understand the biological function of lncRNAs.
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影响因子：
2.8
作者：
Hu D;Zhong T;Dai Q
通讯作者：
Dai Q
影响因子：
50.3
作者：
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影响因子：
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