A role for the cortex in sleep-wake regulation.

A role for the cortex in sleep-wake regulation.
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DOI:
10.1038/s41593-021-00894-6
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发表时间:
2021-09
影响因子:
25
通讯作者:
Vyazovskiy VV
Vyazovskiy VV
中科院分区:
医学1区
文献类型:
--
作者:
Krone LB;Yamagata T;Blanco-Duque C;Guillaumin MCC;Kahn MC;van der Vinne V;McKillop LE;Tam SKE;Peirson SN;Akerman CJ;Hoerder-Suabedissen A;Molnár Z;Vyazovskiy VV

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皮质和皮质下回路被认为分别在睡眠振荡和全局状态控制的产生中发挥不同的作用。在这里,我们沉默了一个子集的新皮质层5锥体和archicortical齿状回颗粒细胞在雄性小鼠通过消融SNAP 25。这显著增加了觉醒和减少睡眠剥夺后EEG慢波活动的反弹,表明皮层在警觉状态控制和睡眠稳态中的作用。
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of EEG slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
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影响因子: --
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