Effects of Hyperferritinemia on Functional Outcome in Acute Ischemic Stroke Patients with Admission Hyperglycemia
Effects of Hyperferritinemia on Functional Outcome in Acute Ischemic Stroke Patients with Admission Hyperglycemia
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高铁蛋白血症对入院高血糖的急性缺血性脑卒中患者功能结局的影响
DOI：
10.1159/000527860
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发表时间：
2022-12
影响因子：
2.9
通讯作者：
Ming Liu
中科院分区：
文献类型：
--
作者：
Qian Wu;Chenchen Wei;Junfeng Liu;Yanan Wang;Ming Liu
前言：高铁血症表现为血清铁蛋白水平升高，是高铁状态的指标，在急性缺血性卒中(AIS)后继发性脑损伤中起作用。然而，高铁蛋白血症和不良结局的影响仍然不确定。此外，AIS患者常伴有入院时的高血糖，这与不良预后有关。因此，我们旨在研究高铁蛋白血症对AIS患者3个月和1年功能结局的影响，尤其是那些入院时有高血糖的患者。方法：选择2016-10/2019年12在西中国医院就诊的发病24小时内的急性脑梗塞患者。入院时检测血清铁蛋白和血糖水平。3个月和1年的功能预后不良定义为改良朗肯评分≥3。采用多变量分析探讨高铁蛋白血症与3个月和1年的预后的关系。对有无高血糖的患者进行亚组分析。结果：最终纳入的723例患者(平均年龄68.11岁，男性60.6%)中，高铁蛋白血症347例(48.0%)。3个月和1年预后不良的发生率分别为45.2%和41.2%。高铁蛋白血症患者3个月预后不良(51.8%比39.2%，p=0.001)和1年预后差(46.8%比36.1%，p=0.004)更高。在所有AIS患者中，在调整混杂因素后的3个月或1年，高铁蛋白血症与功能预后不良没有独立的相关性(均p3e；0.05)。在伴有高血糖的急性脑梗塞患者中，高铁蛋白血症与不良的3个月预后相关(OR=1.711，95%CI 1.093~2.681，p=0.019)，但与不良的1年预后无关(p3e；0.019)。结论：在伴有高血糖的AIS患者中，高铁状态表现为高铁蛋白血症，与较差的3个月功能预后有关。评估血清铁蛋白水平可能有助于评估伴有高血糖的AIS患者短期不良预后的风险。我们还需要进一步的研究来证实我们的发现。
Introduction: Hyperferritinemia, presented as elevated serum ferritin level, is an indicator of high iron status which plays roles in secondary brain injury after acute ischemic stroke (AIS). However, the effects of hyperferritinemia and poor outcomes remain uncertain. Additionally, admission hyperglycemia quite frequently accompanies AIS patients, which is associated with unfavorable outcome. Thus, we aimed to investigate the effects of hyperferritinemia on 3-month and 1-year functional outcomes in AIS patients and especially those with admission hyperglycemia. Methods: AIS patients within 24 h of onset were enrolled at West China Hospital from October 2016 to December 2019. Serum ferritin and blood glucose levels were tested on admission. Poor functional outcome at 3 months and 1 year was defined as modified Rankin Scale score ≥3. Multivariable analysis was used to investigate the associations between hyperferritinemia and 3-month and 1-year outcomes. Subgroup analysis was performed in patients with and without hyperglycemia. Results: Of 723 patients (mean age 68.11 years, 60.6% males) finally included, 347 (48.0%) had hyperferritinemia. The incidence of poor outcome was 45.2% at 3 months and 41.2% at 1 year. Patients with hyperferritinemia had a higher frequency of poor 3-month outcome (51.8% vs. 39.2%, p = 0.001) and poor 1-year outcome (46.8% vs. 36.1%, p = 0.004). In all AIS patients, hyperferritinemia was not independently associated with poor functional outcome at 3 months or 1 year after adjusting for confounders (all p 3e; 0.05). In AIS patients with hyperglycemia, hyperferritinemia was an independent factor correlated with poor 3-month outcome (OR = 1.711, 95% CI 1.093–2.681, p = 0.019) but not with poor 1-year outcome (p 3e; 0.05). Conclusions: High iron status, presented as hyperferritinemia, is associated with poor 3-month functional outcome in AIS patients with hyperglycemia. Evaluating serum ferritin level may be conducive to assess the risk of short-term poor outcome in AIS patients with hyperglycemia. Further studies will be required to confirm our findings.
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影响因子：
7.6
作者：
Liao CC;Chen YF;Xiao F
通讯作者：
Xiao F
影响因子：
2.2
作者：
Aslihan Kusvuran Ozkan;O. Umit Yemisci;Sacide Nur Saraçgil Coşar;Pinar Oztop;N. Turhan
通讯作者：
Aslihan Kusvuran Ozkan;O. Umit Yemisci;Sacide Nur Saraçgil Coşar;Pinar Oztop;N. Turhan
DOI：
10.1016/j.jstrokecerebrovasdis.2012.10.013
发表时间：
2013-10-01
影响因子：
2.5
作者：
Chakraborty, Baidarbhi;Vishnoi, Gaurav;Agarwal, Sarita
通讯作者：
Agarwal, Sarita
影响因子：
6.9
作者：
Abdul Y;Li W;Ward R;Abdelsaid M;Hafez S;Dong G;Jamil S;Wolf V;Johnson MH;Fagan SC;Ergul A
通讯作者：
Ergul A
影响因子：
3.3
作者：
Honglian Shi;Mohammed M. A. Almutairi;J. Moskovitz;Yuexia Xu
通讯作者：
Honglian Shi;Mohammed M. A. Almutairi;J. Moskovitz;Yuexia Xu