It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host.
It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host.
复制标题
DOI：
10.1002/yea.3222
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Nielsen K
中科院分区：
文献类型：
--
作者：
Gerstein AC;Nielsen K
隐球菌主要是一种与艾滋病相关的病原体，在免疫功能低下的患者中引起显著的发病率和死亡率。历史上，研究重点是通过使用体内和体外模型系统来识别毒力因子，从而了解生物体如何导致人类疾病。然而，隐球菌不是一种专性病原体，因为人与人之间的传播要么不存在，要么很罕见。因此，环境中的选择必须被用来塑造这一类群的进化，并直接影响基因型和性状的多样性。重要的是，致病性的进化和维持也必须直接来自环境选择。为此，在这里，我们研究了环境中的非生物和生物胁迫，并讨论了它们如何塑造通常被认为是重要毒力性状的因素。我们确定了一些关于隐球菌多样性和进化的重要未回答的问题，这些问题对于理解这种致命的病原体至关重要，并讨论了如何利用现代采样和基因组工具来回答这些问题。
Cryptococcus is predominantly an AIDS-related pathogen that causes significant morbidity and mortality in immunocompromised patients. Research studies have historically focused on understanding how the organism causes human disease through the use of in vivo and in vitro model systems to identify virulence factors. Cryptococcus is not an obligate pathogen, however, as human–human transmission is either absent or rare. Selection in the environment must thus be invoked to shape the evolution of this taxa, and directly influences genotypic and trait diversity. Importantly, the evolution and maintenance of pathogenicity must also stem directly from environmental selection. To that end, here we examine abiotic and biotic stresses in the environment, and discuss how they could shape the factors that are commonly identified as important virulence traits. We identify a number of important unanswered questions about Cryptococcus diversity and evolution that are critical for understanding this deadly pathogen, and discuss how implementation of modern sampling and genomic tools could be utilized to answer these questions.
登录
查看更多内容
影响因子：
3
作者：
da Silva, EG;Baroni, FD;Paula, CR
通讯作者：
Paula, CR
影响因子：
3.1
作者：
Cox, GM;Mukherjee, J;Perfect, JR
通讯作者：
Perfect, JR
影响因子：
2.9
作者：
Connolly, JH;Krockenberger, MB;Muir, DB
通讯作者：
Muir, DB
影响因子：
6.4
作者：
Alanio, Alexandre;Vernel-Pauillac, Frederique;Dromer, Francoise
通讯作者：
Dromer, Francoise
影响因子：
4.4
作者：
Chrisman, Cara J.;Alvarez, Mauricio;Casadevall, Arturo
通讯作者：
Casadevall, Arturo