Global Tracking in Human Gliomas: A Comparison with Established Tracking Methods
Global Tracking in Human Gliomas: A Comparison with Established Tracking Methods
复制标题
人类神经胶质瘤的全局追踪：与现有追踪方法的比较
DOI：
10.1007/s00062-013-0198-x
复制
发表时间：
2013
影响因子：
2.8
通讯作者：
I. Mader
中科院分区：
文献类型：
--
作者：
T. Nguyen-Thanh;M. Reisert;C. Anastasopoulos;F. Hamzei;T. Reithmeier;M.S. Vry;V.G. Kiselev;A. Weyerbrock;I. Mader
全局跟踪（GT）是最近提出的一种同时考虑所有纤维重建过程的纤维束成像（FT）方法。本研究的目的是比较这种新方法与纤维分配连续跟踪（FACT）和概率束摄影（PT）检测神经胶质瘤患者的皮质脊髓束（CST）。方法对17例位于运动皮层或皮质脊髓束的低级别星形细胞瘤8例，间变性星形细胞瘤9例进行CST造影。得到了分数各向异性（FA）、平均（MD）、轴向（AD）和径向扩散率（RD）等扩散指标。此外，将这些方法应用于物理模型以评估其准确性。结果PT患者全部成功（100%），GT患者16例（94%），FACT患者15例（88%）。GT和FACT同时错过CST的情况下AD和RD最高，而单独使用FACT算法未成功的情况下AD和RD最低。病理侧FA减少（FApath为0.35±0.16 (mean±SD)，对侧FA为0.51±0.15,p < 0.03）。病理侧RD增加（RDpath为0.67±0.29 × 10−3 mm2/s，对侧RDpath为0.46±0.08 × 10−3 mm2/s, p < 0.03）。在幻像测量中，只有GT没有在纤维交叉点检测到假阳性纤维。结论即使在弥散性增加的区域，表明严重的水肿或组织解体，PT也能很好地发挥作用。FACT也容易受到扩散系数降低和敏感性伪影的影响，其中GT是健壮的。
Purpose Global tracking (GT) is a recently published fibre tractography (FT) method that takes simultaneously all fibres into account during their reconstruction. The purpose of this study was to compare this new method with fibre assignment by continuous tracking (FACT) and probabilistic tractography (PT) for the detection of the corticospinal tract (CST) in patients with gliomas. Methods Tractography of the CST was performed in 17 patients with eight low grade and nine anaplastic astrocytomas located in the motor cortex or the corticospinal tract. Diffusions metrics as fractional anisotropy (FA), mean (MD), axial (AD) and radial diffusivity (RD) were obtained. The methods were additionally applied on a physical phantom to assess their accuracy. Results PT was successful in all (100 %), GT in 16 (94 %) and FACT in 15 patients (88 %). The case where GT and FACT, both, missed the CST showed the highest AD and RD, whereas the one where FACT algorithm, alone, was not successfully showed the lowest AD and RD of the group. FA was reduced on the pathologic side (FApath 0.35 ± 0.16 (mean ± SD) versus FAcontralateral 0.51 ± 0.15, p corr < 0.03). RD was increased on the pathologic side (RDpath 0.67 ± 0.29 × 10− 3 mm2/s versus RDcontralateral 0.46 ± 0.08 × 10− 3 mm2/s, p corr < 0.03). In the phantom measurement, only GT did not detect false positive fibres at fibre crossings. Conclusion PT performed well even in areas of increased diffusivities indicating a severe oedema or disintegration of tissue. FACT was also susceptible to a decrease of diffusivities and to a susceptibility artefact, where GT was robust.
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DOI：
10.1073/pnas.96.18.10422
发表时间：
1999-08-31
影响因子：
11.1
作者：
Conturo, TE;Lori, NF;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.1
作者：
Morita, KI;Matsuzawa, H;Nakada, T
通讯作者：
Nakada, T
影响因子：
4.4
作者：
Pannek, Kerstin;Chalk, Jonathan B.;Rose, Stephen E.
通讯作者：
Rose, Stephen E.
影响因子：
5.7
作者：
Reisert, Marco;Mader, Irina;Kiselev, Valerij
通讯作者：
Kiselev, Valerij