Sex differences in circadian timing systems: implications for disease.
Sex differences in circadian timing systems: implications for disease.
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DOI：
10.1016/j.yfrne.2013.11.003
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发表时间：
2014-01
影响因子：
7.4
通讯作者：
Silver, Rae
中科院分区：
文献类型：
--
作者：
Bailey, Matthew;Silver, Rae
实际上，每一个真核细胞都有内源性生物钟和生理性别。这些基于细胞的时钟被定义为振荡器，其相位可以通过激素等内部信号和光线等外部信号来重置。本综述强调了生物钟与性别差异之间的相互关系。在哺乳动物中，视交叉上核（SCN）作为一个主时钟，同步整个身体的时钟阶段。性腺类固醇受体几乎在所有接受SCN直接输入的部位表达。本文综述了下丘脑-垂体-性腺轴（HPG）、下丘脑-肾上腺-垂体轴（HPA）和睡眠唤醒系统中昼夜节律系统的性别差异。我们还指出，在这些系统中，昼夜节律的破坏因性别而异，并与功能障碍和疾病有关。了解性别差异的昼夜节律系统可以改善这些疾病的治疗策略。
Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex. These cell-based clocks have been conceptualized as oscillators whose phase can be reset by internal signals such as hormones, and external cues such as light. The present review highlights the inter-relationship between circadian clocks and sex differences. In mammals, the suprachiasmatic nucleus (SCN) serves as a master clock synchronizing the phase of clocks throughout the body. Gonadal steroid receptors are expressed in almost every site that receives direct SCN input. Here we review sex differences in the circadian timing system in the hypothalamic-pituitary-gonadal axis (HPG), the hypothalamicadrenal-pituitary (HPA) axis, and sleep-arousal systems. We also point to ways in which disruption of circadian rhythms within these systems differs in the sexes and is associated with dysfunction and disease. Understanding sex differentiated circadian timing systems can lead to improved treatment strategies for these conditions.
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