Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets.
Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets.
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DOI：
10.1038/s41598-021-93855-9
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发表时间：
2021-07-15
影响因子：
4.6
通讯作者：
Kelvin AA
中科院分区：
文献类型：
--
作者：
Francis ME;Richardson B;Goncin U;McNeil M;Rioux M;Foley MK;Ge A;Pechous RD;Kindrachuk J;Cameron CM;Richardson C;Lew J;Machtaler S;Cameron MJ;Gerdts V;Falzarano D;Kelvin AA
SARS-CoV-2（严重急性呼吸道综合征冠状病毒2）住院和死亡对男性和老年人造成了不利影响。在这里，我们研究了男性性别和年龄的影响，比较性别匹配或年龄匹配的雪貂感染SARS-CoV-2。雄性雪貂的体温调节存在差异，感染后上呼吸道病毒复制延长。对鼻甲骨的基因表达分析表明，1岁的雌性雪貂感染后干扰素应答基因显著增加，而雄性雪貂的干扰素应答基因延迟增加。这些结果提供了对COVID-19的深入了解，并表明由于抗病毒反应降低，老年男性可能在病毒传播中发挥作用。
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
Casanova JL
DOI：
10.1016/j.ajpath.2019.09.017
发表时间：
2020-01
期刊：
The American journal of pathology
影响因子：
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作者：
Belser JA;Eckert AM;Huynh T;Gary JM;Ritter JM;Tumpey TM;Maines TR
通讯作者：
Maines TR
影响因子：
3.7
作者：
Danesh A;Cameron CM;León AJ;Ran L;Xu L;Fang Y;Kelvin AA;Rowe T;Chen H;Guan Y;Jonsson CB;Cameron MJ;Kelvin DJ
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Kelvin DJ
DOI：
10.4049/jimmunol.1601896
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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通讯作者：
Perlman S
影响因子：
6
作者：
Bissel, Stephanie J.;Carter, Chalise E.;Ross, Ted M.
通讯作者：
Ross, Ted M.