Controlling the Nucleation and Growth of Salt from Bodily Fluid for Enhanced Biosensing Applications.
Controlling the Nucleation and Growth of Salt from Bodily Fluid for Enhanced Biosensing Applications.
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DOI：
10.3390/bios13121016
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发表时间：
2023-12-06
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影响因子：
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表面增强拉曼光谱（SERS）是医学诊断中的一种变革性工具，特别是用于早期检测关键生物标志物，如小细胞外囊泡（sev）。其无与伦比的灵敏度和与复杂的生物样品的兼容性使其成为革命性的非侵入性诊断方法的理想候选者。然而，影响其有效性的一个重大挑战是吞吐量限制，这主要取决于热点和sEV在很小范围内共定位的先决条件。本文深入探讨了这一问题，介绍了一种利用结晶-成核和生长原理的从未尝试过的方法。通过协同耦合激光与等离子共振，我们解决了与分析物液滴干燥方法和臭名昭著的咖啡环效应相关的挑战。我们的方法根植于对结晶材料科学的深刻理解，显示出显著增加可达等离子体热点的面密度和有效引导外泌体到指定区域的潜力。通过这样做，我们不仅克服了吞吐量的挑战，而且还承诺在微创生物传感领域实现范式转变，为危及生命的疾病带来先进的诊断能力。
Surface-enhanced Raman spectroscopy (SERS) represents a transformative tool in medical diagnostics, particularly for the early detection of key biomarkers such as small extracellular vesicles (sEVs). Its unparalleled sensitivity and compatibility with intricate biological samples make it an ideal candidate for revolutionizing noninvasive diagnostic methods. However, a significant challenge that mars its efficacy is the throughput limitation, primarily anchored in the prerequisite of hotspot and sEV colocalization within a minuscule range. This paper delves deep into this issue, introducing a never-attempted-before approach which harnesses the principles of crystallization—nucleation and growth. By synergistically coupling lasers with plasmonic resonances, we navigate the challenges associated with the analyte droplet drying method and the notorious coffee ring effect. Our method, rooted in a profound understanding of crystallization’s materials science, exhibits the potential to significantly increase the areal density of accessible plasmonic hotspots and efficiently guide exosomes to defined regions. In doing so, we not only overcome the throughput challenge but also promise a paradigm shift in the arena of minimally invasive biosensing, ushering in advanced diagnostic capabilities for life-threatening diseases.
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影响因子：
5.9
作者：
Liu, Zirui;Li, Tieyi;Wang, Zeyu;Liu, Jun;Huang, Shan;Min, Byoung Hoon;An, Ji Young;Kim, Kyoung Mee;Kim, Sung;Chen, Yiqing;Liu, Huinan;Kim, Yong;Wong, David T. W.;Huang, Tony Jun;Xie, Ya-Hong
通讯作者：
Xie, Ya-Hong
DOI：
10.3390/bios6020014
发表时间：
2016-04-14
期刊：
Biosensors
影响因子：
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作者：
Dak P;Ebrahimi A;Swaminathan V;Duarte-Guevara C;Bashir R;Alam MA
通讯作者：
Alam MA
影响因子：
10.8
作者：
Adleman, James R.;Boyd, David A.;Psaltis, Demetri
通讯作者：
Psaltis, Demetri
影响因子：
4.4
作者：
Kaya, D.;Belyi, V. A.;Muthukumar, M.
通讯作者：
Muthukumar, M.
DOI：
10.1002/adsr.202200039
发表时间：
2023-04-01
期刊：
ADVANCED SENSOR RESEARCH
影响因子：
--
作者：
Li, Xinyue;Keshavarz, Meysam;Thompson, Alex J.
通讯作者：
Thompson, Alex J.