Psychosocial problems and recruitment of incentive neurocircuitry: exploring individual differences in healthy adolescents.
Psychosocial problems and recruitment of incentive neurocircuitry: exploring individual differences in healthy adolescents.
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DOI：
10.1016/j.dcn.2011.07.005
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发表时间：
2011-10
影响因子：
4.7
通讯作者：
Hommer, Daniel W.
中科院分区：
文献类型：
--
作者：
Bjork, James M.;Smith, Ashley R.;Chen, Gang;Hommer, Daniel W.
大脑对奖励的反应的成熟差异与青少年因行为相关原因而受伤和死亡的比例增加有关。然而，这种发病率大多与药物中毒或其他外化行为有关，并且可能集中在具有社会心理或神经生物学风险的青少年子集中。为了研究心理社会和行为症状的个体差异是否与动机性神经回路的激活有关，我们使用功能磁共振成像扫描了26名精神健康的青少年，他们正在执行金钱激励延迟任务。药物使用筛选量表（dusii - opd）的总体问题密度与预期奖励反应（与无奖励反应）时腹侧中额叶皮质（mFC）的激活呈正相关。此外，dusii - opd还与赢得奖励预期反应期间的右侧腹侧纹状体招募呈正相关（相对于没有奖励或避免相同程度的损失的反应）。最后，一项心理生理相互作用（PPI）分析表明，伏隔核与部分前扣带和mFC之间的连通性增加作为奖励前景的函数也与DUSI-OPD相关。这些发现扩展了先前的报告，表明在青少年中，动机神经回路反应性的个体差异与冲动或外化行为的不同方面有关。
Maturational differences in brain responsiveness to rewards have been implicated in the increased rates of injury and death in adolescents from behavior-related causes. However, much of this morbidity is related to drug intoxication or other externalizing behaviors, and may be concentrated in a subset of adolescents who are at psychosocial or neurobiological risk. To examine whether individual differences in psychosocial and behavioral symptomatology relate to activation of motivational neurocircuitry, we scanned 26 psychiatrically-healthy adolescents using fMRI as they performed a monetary incentive delay task. Overall Problem Density on the Drug Use Screening Inventory (DUSI-OPD) correlated positively with activation of ventral mesofrontal cortex (mFC) during anticipation of responding for rewards (versus responding for no incentive). In addition, DUSI-OPD also correlated positively with right ventral striatum recruitment during anticipation of responding to win rewards (versus responding for no incentive or to avoid losses of identical magnitudes). Finally, a psychophysiological interaction (PPI) analysis indicated that increased connectivity between nucleus accumbens and portions of anterior cingulate and mFC as a function of reward prospects also correlated with DUSI-OPD. These findings extend previous reports demonstrating that in adolescents, individual differences in reactivity of motivational neurocircuitry relate to different facets of impulsivity or externalizing behaviors.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
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通讯作者：
Glimcher, Paul W.
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作者：
Knutson, B;Cooper, JC
通讯作者：
Cooper, JC
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW