The quality of life in acromegalic patients with biochemical remission by surgery alone is superior to that in those with pharmaceutical therapy without radiotherapy, using the newly developed Japanese version of the AcroQoL
The quality of life in acromegalic patients with biochemical remission by surgery alone is superior to that in those with pharmaceutical therapy without radiotherapy, using the newly developed Japanese version of the AcroQoL
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使用新开发的日本版 AcroQoL，仅通过手术实现生化缓解的肢端肥大症患者的生活质量优于仅接受药物治疗而无需放疗的患者
DOI：
10.1007/s11102-015-0665-2
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发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Takahashi Y.
中科院分区：
文献类型：
--
作者：
Yoshida K;Fukuoka H;Matsumoto R;Bando H;Suda K;Nishizawa H;Iguchi G;Ogawa W;Webb SM;Takahashi Y.
PurposeTo开发一个日本版本的肢端肥大症的生活质量（QoL）问卷（AcroQoL），并探讨与损害的QoL的患者acromegaly.MethodsWe开发了一个日本版本的AcroQoL由一个向前向后的方法和评价QoL在38例肢端肥大症患者谁已在门诊随访科比大学医院。它的可靠性进行了检查Cronbach的α和项目总相关。第二次检查进行并行效度评估的相关性与简表-36（SF-36）和纵向分析的AcroQoL在25 patients.ResultsCronbach的α和项目总相关性显示的范围为0.76-0.93和0.20-0.84，分别，和显着的相关性之间的AcroQoL和SF-36。多变量线性回归分析显示，年龄较小和放疗史与总评分较差相关（分别为p= 0.020和p = 0.042）。有趣的是，在排除接受放疗的患者后的生化对照组中，仅接受手术的患者表现出更高的心理健康水平。（75.0 vs. 65.7%，p= 0.036）和外观（64.3 vs. 53.6%，p= 0.036）得分比那些谁是治疗药物therapy.ConclusionsThe日本版的AcroQoL的可靠性是令人满意的。肢端肥大症患者的生活质量较低与年龄较小和放疗史有关。在生化控制的肢端肥大症中，单独接受手术的患者比接受药物治疗的患者表现出更好的生活质量。
PurposeTo develop a Japanese version of the acromegaly quality of life (QoL) questionnaire (AcroQoL) and investigate the factors associated with impaired QoL in patients with acromegaly.MethodsWe developed a Japanese version of the AcroQoL by a forward–backward method and evaluated QoL in 38 patients with acromegaly who had been followed up at an outpatient clinic at Kobe University Hospital. Its reliability was examined with Cronbach’s alpha and item–total correlations. Second examination was performed for concurrent validity by assessment of correlations with the Short Form-36 (SF-36) and longitudinal analysis of the AcroQoL in 25 patients.ResultsCronbach’s alpha and item–total correlations showed a range of 0.76–0.93 and 0.20–0.84, respectively, and significant correlations were found between the AcroQoL and the SF-36. Younger age and a history of radiotherapy were associated with worse total score by the multivariate linear regression analysis (p= 0.020 andp= 0.042, respectively). Intriguingly, in the biochemically-controlled group after the exclusion of patients who received radiotherapy, patients who underwent surgery alone exhibited a higher psychological (75.0 vs. 65.7 %,p= 0.036) and appearance (64.3 vs. 53.6 %,p= 0.036) score than those who are treating with pharmaceutical therapy.ConclusionsThe reliability of the Japanese version of the AcroQoL was satisfactory. Younger age and a history of radiotherapy were associated with lower QoL in patients with acromegaly. In biochemically-controlled acromegaly, patients who underwent surgery alone exhibited better QoL than those under pharmaceutical therapy.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
3.8
作者：
Tutuncu, Yasemin;Berker, Dilek;Isik, Serhat;Ozuguz, Ufuk;Akbaba, Gulhan;Kucukler, Ferit Kerim;Aydin, Yusuf;Guler, Serdar
通讯作者：
Guler, Serdar
影响因子：
3.8
作者：
Melmed, Shlomo;Cook, David;Schopohl, Jochen;Goth, Miklos I.;Lam, Karen S. L.;Marek, Josef
通讯作者：
Marek, Josef
0021-972X/05/$15.00/0 临床内分泌与代谢杂志 90(1):84–90 美国印刷版权所有 © 2005 by The Endocrine Society doi: 10.1210/jc.2004-0240 结肠镜筛查和随访肢端肥大症患者：多中心研究
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
R. Nascimbeni;F. Fabio;E. Betta;P. Mariani;S. Fisogni;V. Villanacci
通讯作者：
V. Villanacci
影响因子：
5.7
作者：
Erridge, Sara C.;Conkey, David S.;Gregor, Anna
通讯作者：
Gregor, Anna