Histamine Signals in Enteric Neuroimmune Interactions a

Histamine Signals in Enteric Neuroimmune Interactions a
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肠道神经免疫相互作用中的组胺信号

DOI:
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发表时间:
1992
影响因子:
5.2
通讯作者:
J. Wood
J. Wood
中科院分区:
综合性期刊3区
文献类型:
--
作者:
J. Wood

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组胺现在被认为是肠道神经免疫通讯中的重要信号物质。它储存在肠肥大细胞的细胞质颗粒中,当肥大细胞对抗原刺激作出反应时释放到细胞外空间。一旦释放,组胺成为肠神经系统的旁分泌信号。它向肠神经系统发出信号,以调用肠道行为的特定神经程序,同时抑制神经系统库中包含的其他程序的操作。组织特定免疫相关程序以消除外来物质或微生物对系统完整性的威胁。该程序由肠粘膜的模式化分泌物与肌肉组织的强有力的推进收缩活动组成。'-'
Histamine is now recognized as an important signal substance in neuroimmune communication in the intestine.' It is stored in cytoplasmic granules of intestinal mast cells and released into the extracellular space when the mast cells degranulate in response to antigenic stimulation. Once released, histamine becomes a paracrine signal to the enteric nervous system. It signals the enteric nervous system to call to action a specific neural program of intestinal behavior while simultaneously suppressing the operation of other programs contained in the nervous system's library. The specific immune-related program is organized to eliminate the threat of a foreign substance or organism to the integrity of the system. The program consists of patterned secretion from the intestinal mucosa in concert with powerful propulsive contractile activity of the musculature.'-'
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