Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality.
Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality.
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DOI：
10.1016/j.bbi.2009.07.001
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发表时间：
2009-11
影响因子：
15.1
通讯作者：
Lotrich, Francis E.
中科院分区：
文献类型：
--
作者：
Prather, Aric A.;Rabinovitz, Mordechai;Pollock, Bruce G.;Lotrich, Francis E.
抑郁症状、睡眠质量差和全身炎症标志物（例如白细胞介素 (IL)-6）常常相关。干扰素-α (IFN-α) 治疗会导致某些人出现重度抑郁症 (MDD)，这为阐明治疗期间 MDD 与睡眠和炎症的关系提供了可能性。特别是，描绘这些因素之间的时间关系可以帮助了解它们的因果关系。为此，对 95 名非抑郁型丙型肝炎患者在 IFN-α 治疗期间进行了连续四个月的前瞻性随访。我们发现治疗前循环IL-6水平较高可预测MDD的发生率（X2(1)=7.7；p<0.05）。时滞混合效应分析支持单向关联，其中 IL-6 预测下个月的 PSQI 评分（F(47, 11.6) = 78.4；p<0.0005），PSQI 评分预测下个月的抑郁贝克抑郁量表 II (BDI) 评分（F(16,22.6) = 3.4；p<0.005）。此外，在任何给定的治疗月份，IL-6 水平预测下个月的 BDI 症状 (F(16,97.5) = 7.3；p<0.0005），反之，BDI 预测下个月的 IL-6 (F(14,7.4) = 5.2；p<0.05）——为抑郁症状和全身炎症之间的正反馈关系提供证据。这些数据进一步证明，高水平的炎症和较差的睡眠质量可能是 IFN-α 诱发抑郁症的危险因素。此外，这些发现强调了睡眠、抑郁和炎症之间存在的复杂时间关系，并支持需要进行进一步的前瞻性研究，以阐明 IFN-α 治疗期间抑郁的动态变化。
Depressive symptoms, poor sleep quality, and systemic markers of inflammation (e.g. interleukin (IL)-6) are frequently associated. Interferon-alpha (IFN-α) therapy results in major depressive disorder (MDD) in some people, offering the possibility to elucidate the relationship of MDD to sleep and inflammation during treatment. In particular, delineating the temporal relations among these factors could help inform their causal relationships. To this end, a cohort of 95 non-depressed hepatitis C patients was followed prospectively for four consecutive months during IFN-α therapy. We found that higher pre-treatment levels of circulating IL-6 predicted incidence of MDD (X2(1)=7.7; p<0.05). Time-lagged mixed-effect analyses supported uni-directional associations in which IL-6 predicted next month’s PSQI scores (F(47, 11.6) = 78.4; p<0.0005), and PSQI scores predicted next month’s depressive Beck Depression Inventory-II (BDI) scores (F(16,22.6) = 3.4; p<0.005). In addition, on any given month of treatment, IL-6 levels predicted BDI symptoms the following month (F(16,97.5) = 7.3; p<0.0005), and conversely BDI predicted next month’s IL-6 (F(14,7.4) = 5.2; p<0.05) – providing evidence for a positive feedback relationship between depressive symptoms and systemic inflammation. These data provide further evidence that high levels of inflammation and poor sleep quality may be risk factors for IFN-α induced depression. Furthermore, these findings highlight the complex temporal relationships that exist among sleep, depression, and inflammation, and support the need for further prospective investigations to elucidate the dynamics that underlie depression during IFN-α treatment.
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影响因子：
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作者：
Cohen, Stanley B.;Emery, Paul;Totoritis, Mark C.
通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
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