An emerging player in knee osteoarthritis: the infrapatellar fat pad.
An emerging player in knee osteoarthritis: the infrapatellar fat pad.
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DOI：
10.1186/ar4422
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发表时间：
2013
影响因子：
4.9
通讯作者：
Kloppenburg M
中科院分区：
文献类型：
--
作者：
Ioan-Facsinay A;Kloppenburg M
近年来，炎症在骨关节炎的发生、发展和临床特征中的作用已成为研究热点。这导致人们认识到滑膜炎是关节炎症的重要来源，并表明滑膜炎与疼痛和骨关节炎进展密切相关。在这篇综述中，我们讨论了另一个可能在疾病发展/进展中发挥作用的新兴炎症来源：髌下脂肪垫（IFP）。本综述的目的是提供一个全面的看法，IFP的病理获得磁共振研究，沿着其表征在细胞和分子水平。此外，我们讨论了可能的功能，在膝关节的病理过程中，通过总结IFP和其他关节组织之间的相互作用的知识，并讨论了亲与抗炎功能，该组织可能有。我们希望这篇综述将提供关于IFP的所有已发表数据的概述，并为未来的研究指明新的方向。
The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an important source of inflammation in the joint and indicated that synovitis is intimately associated with pain and osteoarthritis progression. In this review, we discuss another emerging source of inflammation that could play a role in disease development/progression: the infrapatellar fat pad (IFP). The aim of this review is to offer a comprehensive view of the pathology of IFP as obtained from magnetic resonance studies, along with its characterization at both the cellular and the molecular level. Furthermore, we discuss the possible function of this organ in the pathological processes in the knee by summarizing the knowledge regarding the interactions between IFP and other joint tissues and discussing the pro- versus anti-inflammatory functions this tissue could have. We hope that this review will offer an overview of all published data regarding the IFP and will indicate novel directions for future research.
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